sod-3 Superoxide dismutase [Mn] 2, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: sod-3
Gene description: Superoxide dismutase [Mn] 2, mitochondrial
Primary source: WormBase:WBGene00004932
Locus tag: CELE_C08A9.1
See related: AllianceGenome:WB:WBGene00004932
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein homodimerization activity and superoxide dismutase activity. Involved in removal of superoxide radicals. Located in mitochondrial respirasome. Is expressed in several structures, including egg-laying apparatus; head; intestine; pharynx; and tail. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); lipid storage disease (multiple); liver disease (multiple); and optic nerve disease (multiple). Orthologous to human SOD2 (superoxide dismutase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: X

Exon count:: 5

Sequence:: Chromosome: X; NC_003284.9 (17092753..17094306)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Baru Pulp (Dipteryx alata Vogel): Fruit from the Brazilian Savanna Protects against Oxidative Stress and Increases the Life Expectancy of Caenorhabditis elegans via SOD-3 and DAF-16.
Title: Baru Pulp (Dipteryx alata Vogel): Fruit from the Brazilian Savanna Protects against Oxidative Stress and Increases the Life Expectancy of Caenorhabditis elegans via SOD-3 and DAF-16.
Data suggest that, under high glucose conditions, mitochondria-mediated oxidative stress and glycation are downstream targets of ins-7; this impairs neuronal system function and longevity via non-neuronal/neuronal crosstalk by affecting sod-3 and glod-4. (ins-7 = insulin related Probable insulin-like peptide beta-type 4; sod-3 = mitochondrial Mn+2 superoxide dismutase; glod-4 = glyoxalase 1)
Title: Reduction in ins-7 gene expression in non-neuronal cells of high glucose exposed Caenorhabditis elegans protects from reactive metabolites, preserves neuronal structure and head motility, and prolongs lifespan.
Interactions of the mitochondrial superoxide dismutases (mtSODs): SOD-2 and SOD-3, are reported.
Title: Novel interactions between mitochondrial superoxide dismutases and the electron transport chain.
identify and analyze the sequence and structure characteristics that ensure the cofactor specificities and the oligomerization modes
Title: Mn/Fe superoxide dismutase interaction fingerprints and prediction of oligomerization and metal cofactor from sequence.
the oxidative stress response genes sod-3 and ctl-2 are required for DAF-16-mediated resistance to Enterococcus faecalis
Title: Oxidative stress enzymes are required for DAF-16-mediated immunity due to generation of reactive oxygen species by Caenorhabditis elegans.

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General gene information

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Markers

C08A9.1 (e-PCR)
- UniSTS:305788

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables manganese ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables superoxide dismutase activity	IBA Inferred from Biological aspect of Ancestor more info
enables superoxide dismutase activity	IDA Inferred from Direct Assay more info	PubMed
enables superoxide dismutase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in reactive oxygen species metabolic process	IEA Inferred from Electronic Annotation more info
involved_in removal of superoxide radicals	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in superoxide metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial respirasome	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Superoxide dismutase [Mn] 2, mitochondrial

NP_510764.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

17092753..17094306

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078363.9 → NP_510764.1 Superoxide dismutase [Mn] 2, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510764.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P41977, Q27469

Conserved Domains (3) summary

PLN02471
Location:5 → 216

PLN02471; superoxide dismutase [Mn]

pfam00081
Location:25 → 106

Sod_Fe_N; Iron/manganese superoxide dismutases, alpha-hairpin domain

pfam02777
Location:112 → 212

Sod_Fe_C; Iron/manganese superoxide dismutases, C-terminal domain