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rab-6.2 Ras-related protein rab-6.2 [ Caenorhabditis elegans ]

Gene ID: 181759, updated on 2-Nov-2024

Summary

Official Symbol
rab-6.2
Official Full Name
Ras-related protein rab-6.2
Primary source
WormBase:WBGene00004270
Locus tag
CELE_T25G12.4
See related
AllianceGenome:WB:WBGene00004270
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables GTP binding activity. Involved in several processes, including early endosome to Golgi transport; positive regulation of feeding behavior; and protein stabilization. Located in Golgi trans cisterna. Is expressed in several structures, including alimentary muscle; hypodermis; nervous system; pharynx; and reproductive system. Orthologous to several human genes including RAB6A (RAB6A, member RAS oncogene family) and RAB6B (RAB6B, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See rab-6.2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
6
Sequence:
Chromosome: X; NC_003284.9 (17222475..17224465)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Medium-chain specific acyl-CoA dehydrogenase, mitochondrial Neighboring gene ncRNA Neighboring gene VWFA domain-containing protein Neighboring gene Rhodanese domain-containing protein Neighboring gene Salivary glue protein Sgs-3-like

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cuticle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in early endosome to Golgi transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mechanosensory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of feeding behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to postsynaptic membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of AMPA receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi apparatus IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in Golgi cisterna IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi trans cisterna IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Ras-related protein rab-6.2
NP_510790.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    17222475..17224465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078389.7NP_510790.1  Ras-related protein rab-6.2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510790.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22782
    UniProtKB/TrEMBL
    I7FW36
    Conserved Domains (2) summary
    smart00175
    Location:11168
    RAB; Rab subfamily of small GTPases
    cd01861
    Location:11171
    Rab6; Rab GTPase family 6 (Rab6)