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F10D7.5 E3 ubiquitin-protein ligase NEURL1B;NHR domain-containing protein;Neuralized-like protein 2 [ Caenorhabditis elegans ]

Gene ID: 181767, updated on 18-Sep-2024

Summary

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Official Symbol
F10D7.5
Official Full Name
E3 ubiquitin-protein ligase NEURL1B;NHR domain-containing protein;Neuralized-like protein 2
Primary source
WormBase:WBGene00017342
Locus tag
CELE_F10D7.5
See related
AllianceGenome:WB:WBGene00017342
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Orthologous to several human genes including NEURL1 (neuralized E3 ubiquitin protein ligase 1) and NEURL1B (neuralized E3 ubiquitin protein ligase 1B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See F10D7.5 in Genome Data Viewer
Location:
chromosome: X
Exon count:
15
Sequence:
Chromosome: X; NC_003284.9 (17383125..17391615, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene CB1 cannabinoid receptor-interacting protein 1 Neighboring gene Galectin;ZP domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SCP domain-containing protein Neighboring gene ShKT domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ITSN-1 controls vesicle recycling at the neuromuscular junction and functions in parallel with DAB-1. Wang W, et al. Traffic, 2008 May. PMID 18298590, Free PMC Article
  2. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
  3. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase NEURL1B;NHR domain-containing protein;Neuralized-like protein 2
NP_001379824.1
  • Partially confirmed by transcript evidence
NP_510817.3
  • Confirmed by transcript evidence
NP_510818.3
  • Confirmed by transcript evidence
NP_510819.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    17383125..17391615 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078417.6 → NP_510818.3  Neuralized-like protein 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510818.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JP67
    Conserved Domains (2) summary
    smart00588
    Location:37 → 158
    NEUZ; domain in neuralized proteins
    cd16647
    Location:565 → 605
    mRING-HC-C3HC5_NEU1; Modified RING finger, HC subclass (C3HC5-type), found in neuralized-like protein NEURL1A, NEURL1B, and similar proteins

  2. NM_078418.4 → NP_510819.3  E3 ubiquitin-protein ligase NEURL1B [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510819.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JP66
    Conserved Domains (2) summary
    smart00588
    Location:68 → 190
    NEUZ; domain in neuralized proteins
    cd16647
    Location:385 → 425
    mRING-HC-C3HC5_NEU1; Modified RING finger, HC subclass (C3HC5-type), found in neuralized-like protein NEURL1A, NEURL1B, and similar proteins

  3. NM_078416.5 → NP_510817.3  NHR domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510817.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JP65
    Conserved Domains (1) summary
    smart00588
    Location:37 → 158
    NEUZ; domain in neuralized proteins

  4. NM_001392919.1 → NP_001379824.1  NHR domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MQ80
    Conserved Domains (1) summary
    smart00588
    Location:37 → 158
    NEUZ; domain in neuralized proteins
Nucleotide Protein
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