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clec-52 C-type lectin domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 181855, updated on 2-Nov-2024

Summary

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Official Symbol
clec-52
Official Full Name
C-type lectin domain-containing protein
Primary source
WormBase:WBGene00015052
Locus tag
CELE_B0218.8
See related
AllianceGenome:WB:WBGene00015052
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable signaling receptor activity. Involved in defense response to Gram-positive bacterium. Is expressed in intestine; nervous system; and pharynx. Orthologous to several human genes including LY75-CD302 (LY75-CD302 readthrough); LY75 (lymphocyte antigen 75); and MRC2 (mannose receptor C-type 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See clec-52 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
7
Sequence:
Chromosome: IV; NC_003282.8 (8167164..8168760, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Fatty acid amide hydrolase 1 Neighboring gene C-type lectin domain-containing protein Neighboring gene Ovule protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Early-life exposure to mycotoxin zearalenone exacerbates aberrant immune response, oxidative stress, and mortality of Caenorhabditis elegans under pathogen Bacillus thuringiensis infection. How CM, et al. Ecotoxicol Environ Saf, 2024 Mar 1. PMID 38342010
  2. Caenorhabditis elegans mounts a p38 MAPK pathway-mediated defence to Cutibacterium acnes infection. Huang X, et al. Cell Microbiol, 2020 Oct. PMID 32543022
  3. Chromosomal clustering and GATA transcriptional regulation of intestine-expressed genes in C. elegans. Pauli F, et al. Development, 2006 Jan. PMID 16354718, Free PMC Article
  4. Determining Toxic Potencies of Water-Soluble Contaminants in Wastewater Influents and Effluent Using Gene Expression Profiling in C. elegans as a Bioanalytical Tool. Karengera A, et al. Arch Environ Contam Toxicol, 2022 Oct. PMID 36190544, Free PMC Article
  5. Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes. Visvikis O, et al. Immunity, 2014 Jun 19. PMID 24882217, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in defense response to Gram-positive bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 

General protein information

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Preferred Names
C-type lectin domain-containing protein
NP_501371.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8167164..8168760 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068970.7 → NP_501371.1  C-type lectin domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501371.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q17452
    Conserved Domains (2) summary
    cd00037
    Location:32 → 147
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    smart00034
    Location:166 → 303
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
Nucleotide Protein
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