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spl-2 Sphingosine Phosphate Lyase [ Caenorhabditis elegans ]

Gene ID: 181859, updated on 2-Nov-2024

Summary

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Official Symbol
spl-2
Official Full Name
Sphingosine Phosphate Lyase
Primary source
WormBase:WBGene00006418
Locus tag
CELE_B0222.4
See related
AllianceGenome:WB:WBGene00006418
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable sphinganine-1-phosphate aldolase activity. Involved in defense response to Gram-positive bacterium. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in nephrotic syndrome type 14. Orthologous to human SGPL1 (sphingosine-1-phosphate lyase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See spl-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (9144619..9146899, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Phosphate transporter Neighboring gene BPTI/Kunitz inhibitor domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Per- and polyfluoroalkyl substances enhance Staphylococcus aureus pathogenicity and impair host immune response. Mangu JCK, et al. Environ Pollut, 2022 Dec 1. PMID 36181932
  2. Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureus. Irazoqui JE, et al. PLoS Pathog, 2010 Jul 1. PMID 20617181, Free PMC Article
  3. Determining Toxic Potencies of Water-Soluble Contaminants in Wastewater Influents and Effluent Using Gene Expression Profiling in C. elegans as a Bioanalytical Tool. Karengera A, et al. Arch Environ Contam Toxicol, 2022 Oct. PMID 36190544, Free PMC Article
  4. Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans. Deng X, et al. Science, 2008 Oct 3. PMID 18832646, Free PMC Article
  5. p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans. Troemel ER, et al. PLoS Genet, 2006 Nov 10. PMID 17096597, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables carbon-carbon lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables sphinganine-1-phosphate aldolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sphingolipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Sphingosine Phosphate Lyase
NP_505372.1
  • Product from WormBase gene class spl;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    9144619..9146899 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072971.7 → NP_505372.1  Sphingosine Phosphate Lyase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505372.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q17456
    Conserved Domains (1) summary
    cd06450
    Location:130 → 493
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
Nucleotide Protein
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