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trx-1 Thioredoxin-1 [ Caenorhabditis elegans ]

Gene ID: 181863, updated on 2-Nov-2024

Summary

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Official Symbol
trx-1
Official Full Name
Thioredoxin-1
Primary source
WormBase:WBGene00015062
Locus tag
CELE_B0228.5
See related
AllianceGenome:WB:WBGene00015062
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein-disulfide reductase activity. Involved in determination of adult lifespan. Located in several cellular components, including dendrite; neuronal cell body; and non-motile cilium. Is expressed in head neurons; intestine; and in male. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See trx-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003280.10 (7752637..7753600, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Copine family protein 2 Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Thioredoxin is related to life span regulation and oxidative stress response in Caenorhabditis elegans. Jee C, et al. Genes Cells, 2005 Dec. PMID 16324156
  2. Lifespan decrease in a Caenorhabditis elegans mutant lacking TRX-1, a thioredoxin expressed in ASJ sensory neurons. Miranda-Vizuete A, et al. FEBS Lett, 2006 Jan 23. PMID 16387300
  3. Thioredoxin shapes the C. elegans sensory response to Pseudomonas produced nitric oxide. Hao Y, et al. Elife, 2018 Jul 17. PMID 30014846, Free PMC Article
  4. Left-right asymmetry in oxidative stress sensing neurons in C. elegans. Quintin S, et al. MicroPubl Biol, 2022. PMID 36338152, Free PMC Article
  5. DNA nanodevices map enzymatic activity in organelles. Dan K, et al. Nat Nanotechnol, 2019 Mar. PMID 30742135, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of thioredoxin-1 in the ASJ neuron corresponds with and enhances intrinsic regenerative capacity under lesion conditioning in C. elegans.
    Title: Expression of thioredoxin-1 in the ASJ neuron corresponds with and enhances intrinsic regenerative capacity under lesion conditioning in C. elegans.
  2. Mitochondrial thioredoxin system is required for enhanced stress resistance and extended longevity in long-lived mitochondrial mutants.
    Title: Mitochondrial thioredoxin system is required for enhanced stress resistance and extended longevity in long-lived mitochondrial mutants.
  3. Trx-1 regulates intestinal SKN-1 nuclear localization in a cell non-autonomous manner.
    Title: TRX-1 Regulates SKN-1 Nuclear Localization Cell Non-autonomously in Caenorhabditis elegans.
  4. TRX-1 is a thioredoxin homolog. Worms lacking this gene display reduced life span and sensitivity toward oxidative stress.
    Title: Thioredoxin is related to life span regulation and oxidative stress response in Caenorhabditis elegans.
  5. TRX-1 acts as a fluctuating neuronal signaling modulator within ASJ neurons to monitor the adjustment of neuropeptide expression, including insulin-like proteins, during dauer formation in response to adverse environmental conditions.
    Title: The thioredoxin TRX-1 modulates the function of the insulin-like neuropeptide DAF-28 during dauer formation in Caenorhabditis elegans.
  6. Dietary restriction activates TRX-1 in ASJ neurons during aging, which in turn triggers TRX-1-dependent mechanisms to extend adult lifespan in the worm.
    Title: The thioredoxin TRX-1 regulates adult lifespan extension induced by dietary restriction in Caenorhabditis elegans.
  7. Suppression of the C. elegans thioredoxin orthologs trx-1 and trx-2, involved in the redox chaperone activity of exo-3, overrides the protective effect of cep-1 RNAi treatment on neuronal integrity, neuronal function, mean and maximum life span.
    Title: Apurinic/apyrimidinic endonuclease 1, p53, and thioredoxin are linked in control of aging in C. elegans.
  8. Data describe a Caenorhabditis elegans thioredoxin (TRX-1), encoded by the gene B0228.5, that is expressed in ASJ ciliated sensory neurons.
    Title: Lifespan decrease in a Caenorhabditis elegans mutant lacking TRX-1, a thioredoxin expressed in ASJ sensory neurons.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein-disulfide reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-disulfide reductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in non-motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Thioredoxin-1
NP_001021885.1
  • Confirmed by transcript evidence
NP_001021886.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    7752637..7753600 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026715.7 → NP_001021886.1  Thioredoxin-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021886.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09433
    Conserved Domains (1) summary
    pfam00085
    Location:7 → 110
    Thioredoxin; Thioredoxin

  2. NM_001026714.4 → NP_001021885.1  Thioredoxin-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021885.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09433, Q306X0, Q7YZF7
    Conserved Domains (1) summary
    pfam00085
    Location:16 → 111
    Thioredoxin; Thioredoxin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09433.1

Gene LinkOut

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