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Nsd1 nuclear receptor-binding SET-domain protein 1 [ Mus musculus (house mouse) ]

Gene ID: 18193, updated on 2-Nov-2024

Summary

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Official Symbol
Nsd1provided by MGI
Official Full Name
nuclear receptor-binding SET-domain protein 1provided by MGI
Primary source
MGI:MGI:1276545
See related
Ensembl:ENSMUSG00000021488 AllianceGenome:MGI:1276545
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KMT3B
Summary
Enables several functions, including nuclear receptor binding activity; protein-lysine N-methyltransferase activity; and transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within gastrulation with mouth forming second. Located in nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; long bone epiphysis; and retina. Human ortholog(s) of this gene implicated in Sotos syndrome; Sotos syndrome 1; acute myeloid leukemia; microcephaly; and neuroblastoma. Orthologous to human NSD1 (nuclear receptor binding SET domain protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 12.4), placenta adult (RPKM 9.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nsd1 in Genome Data Viewer
Location:
13 B1; 13 29.8 cM
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (55357595..55466138)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (55209782..55318325)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 346 Neighboring gene predicted gene, 46415 Neighboring gene fibroblast growth factor receptor 4 Neighboring gene STARR-positive B cell enhancer ABC_E5399 Neighboring gene STARR-seq mESC enhancer starr_34607 Neighboring gene STARR-seq mESC enhancer starr_34609 Neighboring gene PRELI domain containing 1 Neighboring gene RAB24, member RAS oncogene family Neighboring gene Max dimerization protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NSD1 deposits histone H3 lysine 36 dimethylation to pattern non-CG DNA methylation in neurons. Hamagami N, et al. Mol Cell, 2023 May 4. PMID 37098340, Free PMC Article
  2. Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas. Li Y, et al. Mol Cell, 2022 Oct 20. PMID 36206767, Free PMC Article
  3. The H3K36me2 methyltransferase NSD1 modulates H3K27ac at active enhancers to safeguard gene expression. Fang Y, et al. Nucleic Acids Res, 2021 Jun 21. PMID 34107030, Free PMC Article
  4. Investigating cortical features of Sotos syndrome using mice heterozygous for Nsd1. Oishi S, et al. Genes Brain Behav, 2020 Apr. PMID 31909872
  5. H3K36 methyltransferase NSD1 protects against osteoarthritis through regulating chondrocyte differentiation and cartilage homeostasis. Shao R, et al. Cell Death Differ, 2024 Jan. PMID 38012390,

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L reveal their distinct contributions to H3K36 methylation.
    Title: Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L reveal their distinct contributions to H3K36 methylation.
  2. H3K36 methyltransferase NSD1 protects against osteoarthritis through regulating chondrocyte differentiation and cartilage homeostasis.
    Title: H3K36 methyltransferase NSD1 protects against osteoarthritis through regulating chondrocyte differentiation and cartilage homeostasis.
  3. Histone methylation mediated by NSD1 is required for the establishment and maintenance of neuronal identities.
    Title: Histone methylation mediated by NSD1 is required for the establishment and maintenance of neuronal identities.
  4. Targeting KDM2A Enhances T-cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma.
    Title: Targeting KDM2A Enhances T-cell Infiltration in NSD1-Deficient Head and Neck Squamous Cell Carcinoma.
  5. NSD1 deposits histone H3 lysine 36 dimethylation to pattern non-CG DNA methylation in neurons.
    Title: NSD1 deposits histone H3 lysine 36 dimethylation to pattern non-CG DNA methylation in neurons.
  6. H3K36 methyltransferase NSD1 is essential for normal B1 and B2 cell development and germinal center formation.
    Title: H3K36 methyltransferase NSD1 is essential for normal B1 and B2 cell development and germinal center formation.
  7. The H3K36me2 methyltransferase NSD1 modulates H3K27ac at active enhancers to safeguard gene expression.
    Title: The H3K36me2 methyltransferase NSD1 modulates H3K27ac at active enhancers to safeguard gene expression.
  8. Investigating cortical features of Sotos syndrome using mice heterozygous for Nsd1.
    Title: Investigating cortical features of Sotos syndrome using mice heterozygous for Nsd1.
  9. NSD1-deposited H3K36me2 directs de novo methylation in the mouse male germline and counteracts Polycomb-associated silencing.
    Title: NSD1-deposited H3K36me2 directs de novo methylation in the mouse male germline and counteracts Polycomb-associated silencing.
  10. Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia.
    Title: Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K36 dimethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K36 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K36 methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K36 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables histone H4K20 methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear androgen receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear androgen receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables nuclear estrogen receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nuclear retinoic acid receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nuclear retinoid X receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nuclear thyroid hormone receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within gastrulation with mouth forming second IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein-containing complex organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within regulation of RNA polymerase II regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
part_of histone methyltransferase complex IC
Inferred by Curator
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
histone-lysine N-methyltransferase, H3 lysine-36 specific
Names
H3-K36-HMTase
H4-K20-HMTase
NR-binding SET domain-containing protein
histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific
nuclear receptor-binding SET domain-containing protein 1
NP_001395627.1
NP_001395628.1
NP_001395629.1
NP_001395630.1
NP_001395631.1
NP_001395632.1
NP_001395633.1
NP_001395634.1
NP_001395635.1
NP_001395636.1
NP_001395637.1
NP_001395638.1
NP_001395639.1
NP_001395640.1
NP_001395641.1
NP_001395642.1
NP_001395643.1
NP_001395644.1
NP_032765.3
XP_006517197.1
XP_006517198.1
XP_006517199.1
XP_006517200.1
XP_006517201.1
XP_006517203.1
XP_006517204.1
XP_006517205.1
XP_006517207.1
XP_006517209.1
XP_006517210.1
XP_006517211.1
XP_030103041.1
XP_030103042.1
XP_030103044.1
XP_030103046.1
XP_030103047.1
XP_036013798.1
XP_036013799.1
XP_036013800.1
XP_036013801.1
XP_036013802.1
XP_036013803.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001408698.1 → NP_001395627.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC160958

  2. NM_001408699.1 → NP_001395628.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC160958

  3. NM_001408700.1 → NP_001395629.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC160958

  4. NM_001408701.1 → NP_001395630.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC160958

  5. NM_001408702.1 → NP_001395631.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC160958

  6. NM_001408703.1 → NP_001395632.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC160958

  7. NM_001408704.1 → NP_001395633.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC160958

  8. NM_001408705.1 → NP_001395634.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC160958

  9. NM_001408706.1 → NP_001395635.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC160958

  10. NM_001408707.1 → NP_001395636.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC160958

  11. NM_001408708.1 → NP_001395637.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC160958

  12. NM_001408709.1 → NP_001395638.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC160958
    UniProtKB/TrEMBL
    A0A286YDS9

  13. NM_001408710.1 → NP_001395639.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC160958
    UniProtKB/TrEMBL
    A0A286YDS9

  14. NM_001408711.1 → NP_001395640.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC160958
    UniProtKB/TrEMBL
    A0A286YDS9
    Related
    ENSMUSP00000152939.2, ENSMUST00000224693.2

  15. NM_001408712.1 → NP_001395641.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC160958
    UniProtKB/TrEMBL
    A0A286YDS9
    Related
    ENSMUSP00000153511.2, ENSMUST00000224918.2

  16. NM_001408713.1 → NP_001395642.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC160958

  17. NM_001408714.1 → NP_001395643.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC160958

  18. NM_001408715.1 → NP_001395644.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC160958

  19. NM_008739.3 → NP_032765.3  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 1

    See identical proteins and their annotated locations for NP_032765.3

    Status: VALIDATED

    Source sequence(s)
    AC160958, AK145783, BI737132, BQ442794, BQ917954, CA318563, CB247038, CD549506, CD806124, CN529078
    Consensus CDS
    CCDS36673.1
    UniProtKB/TrEMBL
    A0A286YE36, E9QAE4
    Related
    ENSMUSP00000097089.3, ENSMUST00000099490.3
    Conserved Domains (12) summary
    cd05837
    Location:320 → 430
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:1755 → 1849
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    PHA03307
    Location:2255 → 2576
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5034
    Location:1453 → 1587
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15648
    Location:1546 → 1587
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1593 → 1639
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1640 → 1693
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1710 → 1749
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:2121 → 2163
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    pfam17907
    Location:1902 → 1940
    AWS; AWS domain
    pfam17982
    Location:2162 → 2211
    C5HCH; NSD Cys-His rich domain
    cd19210
    Location:1942 → 2083
    SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    55357595..55466138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517146.3 → XP_006517209.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

    See identical proteins and their annotated locations for XP_006517209.1

    UniProtKB/TrEMBL
    A0A286YE36
    Conserved Domains (12) summary
    cd05837
    Location:50 → 160
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:1485 → 1579
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    PHA03307
    Location:1985 → 2306
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5034
    Location:1183 → 1317
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15648
    Location:1276 → 1317
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1323 → 1369
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1370 → 1423
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1440 → 1479
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:1851 → 1893
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd19210
    Location:1672 → 1813
    SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
    pfam17907
    Location:1632 → 1670
    AWS; AWS domain
    pfam17982
    Location:1892 → 1941
    C5HCH; NSD Cys-His rich domain

  2. XM_030247184.2 → XP_030103044.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

    UniProtKB/TrEMBL
    A0A286YE36
    Conserved Domains (12) summary
    cd05837
    Location:50 → 160
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:1485 → 1579
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    PHA03307
    Location:1985 → 2306
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5034
    Location:1183 → 1317
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15648
    Location:1276 → 1317
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1323 → 1369
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1370 → 1423
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1440 → 1479
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:1851 → 1893
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd19210
    Location:1672 → 1813
    SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
    pfam17907
    Location:1632 → 1670
    AWS; AWS domain
    pfam17982
    Location:1892 → 1941
    C5HCH; NSD Cys-His rich domain

  3. XM_006517138.5 → XP_006517201.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

    See identical proteins and their annotated locations for XP_006517201.1

    UniProtKB/TrEMBL
    A0A286YE36, E9QAE4
    Conserved Domains (12) summary
    cd05837
    Location:320 → 430
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:1755 → 1849
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    PHA03307
    Location:2255 → 2576
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5034
    Location:1453 → 1587
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15648
    Location:1546 → 1587
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1593 → 1639
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1640 → 1693
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1710 → 1749
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:2121 → 2163
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    pfam17907
    Location:1902 → 1940
    AWS; AWS domain
    pfam17982
    Location:2162 → 2211
    C5HCH; NSD Cys-His rich domain
    cd19210
    Location:1942 → 2083
    SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins

  4. XM_006517144.3 → XP_006517207.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

    See identical proteins and their annotated locations for XP_006517207.1

    UniProtKB/TrEMBL
    A0A286YE36
    Conserved Domains (12) summary
    cd05837
    Location:50 → 160
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:1485 → 1579
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    PHA03307
    Location:1985 → 2306
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5034
    Location:1183 → 1317
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15648
    Location:1276 → 1317
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1323 → 1369
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1370 → 1423
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1440 → 1479
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:1851 → 1893
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd19210
    Location:1672 → 1813
    SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
    pfam17907
    Location:1632 → 1670
    AWS; AWS domain
    pfam17982
    Location:1892 → 1941
    C5HCH; NSD Cys-His rich domain

  5. XM_006517137.4 → XP_006517200.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

    See identical proteins and their annotated locations for XP_006517200.1

    UniProtKB/TrEMBL
    A0A286YE36, E9QAE4
    Conserved Domains (12) summary
    cd05837
    Location:320 → 430
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:1755 → 1849
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    PHA03307
    Location:2255 → 2576
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5034
    Location:1453 → 1587
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15648
    Location:1546 → 1587
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1593 → 1639
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1640 → 1693
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1710 → 1749
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:2121 → 2163
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    pfam17907
    Location:1902 → 1940
    AWS; AWS domain
    pfam17982
    Location:2162 → 2211
    C5HCH; NSD Cys-His rich domain
    cd19210
    Location:1942 → 2083
    SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins

  6. XM_036157908.1 → XP_036013801.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X3

    UniProtKB/TrEMBL
    A0A286YE36
    Conserved Domains (11) summary
    cd05838
    Location:1370 → 1464
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    PHA03307
    Location:1870 → 2191
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5034
    Location:1068 → 1202
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15648
    Location:1161 → 1202
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1208 → 1254
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1255 → 1308
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1325 → 1364
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:1736 → 1778
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd19210
    Location:1557 → 1698
    SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
    pfam17907
    Location:1517 → 1555
    AWS; AWS domain
    pfam17982
    Location:1777 → 1826
    C5HCH; NSD Cys-His rich domain

  7. XM_030247181.2 → XP_030103041.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

    UniProtKB/TrEMBL
    A0A286YE36, E9QAE4
    Conserved Domains (12) summary
    cd05837
    Location:320 → 430
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:1755 → 1849
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    PHA03307
    Location:2255 → 2576
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5034
    Location:1453 → 1587
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15648
    Location:1546 → 1587
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1593 → 1639
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1640 → 1693
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1710 → 1749
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:2121 → 2163
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    pfam17907
    Location:1902 → 1940
    AWS; AWS domain
    pfam17982
    Location:2162 → 2211
    C5HCH; NSD Cys-His rich domain
    cd19210
    Location:1942 → 2083
    SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins

  8. XM_006517140.5 → XP_006517203.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

    See identical proteins and their annotated locations for XP_006517203.1

    UniProtKB/TrEMBL
    A0A286YE36, E9QAE4
    Conserved Domains (12) summary
    cd05837
    Location:320 → 430
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:1755 → 1849
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    PHA03307
    Location:2255 → 2576
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5034
    Location:1453 → 1587
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15648
    Location:1546 → 1587
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1593 → 1639
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1640 → 1693
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1710 → 1749
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:2121 → 2163
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    pfam17907
    Location:1902 → 1940
    AWS; AWS domain
    pfam17982
    Location:2162 → 2211
    C5HCH; NSD Cys-His rich domain
    cd19210
    Location:1942 → 2083
    SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins

  9. XM_036157910.1 → XP_036013803.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X3

    UniProtKB/TrEMBL
    A0A286YE36
    Conserved Domains (11) summary
    cd05838
    Location:1370 → 1464
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    PHA03307
    Location:1870 → 2191
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5034
    Location:1068 → 1202
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15648
    Location:1161 → 1202
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1208 → 1254
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1255 → 1308
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1325 → 1364
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:1736 → 1778
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd19210
    Location:1557 → 1698
    SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
    pfam17907
    Location:1517 → 1555
    AWS; AWS domain
    pfam17982
    Location:1777 → 1826
    C5HCH; NSD Cys-His rich domain

  10. XM_030247186.2 → XP_030103046.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

    UniProtKB/TrEMBL
    A0A286YE36
    Conserved Domains (12) summary
    cd05837
    Location:50 → 160
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:1485 → 1579
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    PHA03307
    Location:1985 → 2306
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5034
    Location:1183 → 1317
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15648
    Location:1276 → 1317
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1323 → 1369
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1370 → 1423
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1440 → 1479
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:1851 → 1893
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd19210
    Location:1672 → 1813
    SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
    pfam17907
    Location:1632 → 1670
    AWS; AWS domain
    pfam17982
    Location:1892 → 1941
    C5HCH; NSD Cys-His rich domain

  11. XM_006517148.4 → XP_006517211.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X4

    Conserved Domains (10) summary
    cd05837
    Location:320 → 430
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:1755 → 1849
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    COG5034
    Location:1453 → 1587
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15648
    Location:1546 → 1587
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1593 → 1639
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1640 → 1693
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1710 → 1749
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    pfam17907
    Location:1902 → 1940
    AWS; AWS domain
    cd19210
    Location:1942 → 2083
    SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
    cl22851
    Location:2121 → 2155
    PHD_SF; PHD finger superfamily

  12. XM_006517136.4 → XP_006517199.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

    See identical proteins and their annotated locations for XP_006517199.1

    UniProtKB/TrEMBL
    A0A286YE36, E9QAE4
    Conserved Domains (12) summary
    cd05837
    Location:320 → 430
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:1755 → 1849
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    PHA03307
    Location:2255 → 2576
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5034
    Location:1453 → 1587
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15648
    Location:1546 → 1587
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1593 → 1639
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1640 → 1693
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1710 → 1749
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:2121 → 2163
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    pfam17907
    Location:1902 → 1940
    AWS; AWS domain
    pfam17982
    Location:2162 → 2211
    C5HCH; NSD Cys-His rich domain
    cd19210
    Location:1942 → 2083
    SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins

  13. XM_006517134.5 → XP_006517197.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

    See identical proteins and their annotated locations for XP_006517197.1

    UniProtKB/TrEMBL
    A0A286YE36, E9QAE4
    Conserved Domains (12) summary
    cd05837
    Location:320 → 430
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:1755 → 1849
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    PHA03307
    Location:2255 → 2576
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5034
    Location:1453 → 1587
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15648
    Location:1546 → 1587
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1593 → 1639
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1640 → 1693
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1710 → 1749
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:2121 → 2163
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    pfam17907
    Location:1902 → 1940
    AWS; AWS domain
    pfam17982
    Location:2162 → 2211
    C5HCH; NSD Cys-His rich domain
    cd19210
    Location:1942 → 2083
    SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins

  14. XM_006517135.5 → XP_006517198.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

    See identical proteins and their annotated locations for XP_006517198.1

    UniProtKB/TrEMBL
    A0A286YE36, E9QAE4
    Conserved Domains (12) summary
    cd05837
    Location:320 → 430
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:1755 → 1849
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    PHA03307
    Location:2255 → 2576
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5034
    Location:1453 → 1587
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15648
    Location:1546 → 1587
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1593 → 1639
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1640 → 1693
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1710 → 1749
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:2121 → 2163
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    pfam17907
    Location:1902 → 1940
    AWS; AWS domain
    pfam17982
    Location:2162 → 2211
    C5HCH; NSD Cys-His rich domain
    cd19210
    Location:1942 → 2083
    SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins

  15. XM_036157906.1 → XP_036013799.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X3

    UniProtKB/TrEMBL
    A0A286YE36
    Conserved Domains (11) summary
    cd05838
    Location:1370 → 1464
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    PHA03307
    Location:1870 → 2191
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5034
    Location:1068 → 1202
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15648
    Location:1161 → 1202
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1208 → 1254
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1255 → 1308
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1325 → 1364
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:1736 → 1778
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd19210
    Location:1557 → 1698
    SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
    pfam17907
    Location:1517 → 1555
    AWS; AWS domain
    pfam17982
    Location:1777 → 1826
    C5HCH; NSD Cys-His rich domain

  16. XM_036157907.1 → XP_036013800.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X3

    UniProtKB/TrEMBL
    A0A286YE36
    Conserved Domains (11) summary
    cd05838
    Location:1370 → 1464
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    PHA03307
    Location:1870 → 2191
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5034
    Location:1068 → 1202
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15648
    Location:1161 → 1202
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1208 → 1254
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1255 → 1308
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1325 → 1364
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:1736 → 1778
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd19210
    Location:1557 → 1698
    SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
    pfam17907
    Location:1517 → 1555
    AWS; AWS domain
    pfam17982
    Location:1777 → 1826
    C5HCH; NSD Cys-His rich domain

  17. XM_030247182.2 → XP_030103042.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

    UniProtKB/TrEMBL
    A0A286YE36
    Conserved Domains (12) summary
    cd05837
    Location:50 → 160
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:1485 → 1579
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    PHA03307
    Location:1985 → 2306
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5034
    Location:1183 → 1317
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15648
    Location:1276 → 1317
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1323 → 1369
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1370 → 1423
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1440 → 1479
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:1851 → 1893
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd19210
    Location:1672 → 1813
    SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
    pfam17907
    Location:1632 → 1670
    AWS; AWS domain
    pfam17982
    Location:1892 → 1941
    C5HCH; NSD Cys-His rich domain

  18. XM_030247187.2 → XP_030103047.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X5

    Conserved Domains (9) summary
    cd05838
    Location:230 → 324
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    PHA03307
    Location:730 → 1051
    PHA03307; transcriptional regulator ICP4; Provisional
    cd15648
    Location:21 → 62
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15653
    Location:115 → 168
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:596 → 638
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    pfam17907
    Location:377 → 415
    AWS; AWS domain
    pfam17982
    Location:637 → 686
    C5HCH; NSD Cys-His rich domain
    cd19210
    Location:417 → 558
    SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
    cl22851
    Location:68 → 114
    PHD_SF; PHD finger superfamily

  19. XM_006517147.3 → XP_006517210.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

    See identical proteins and their annotated locations for XP_006517210.1

    UniProtKB/TrEMBL
    A0A286YE36
    Conserved Domains (12) summary
    cd05837
    Location:50 → 160
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:1485 → 1579
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    PHA03307
    Location:1985 → 2306
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5034
    Location:1183 → 1317
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15648
    Location:1276 → 1317
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1323 → 1369
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1370 → 1423
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1440 → 1479
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:1851 → 1893
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd19210
    Location:1672 → 1813
    SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
    pfam17907
    Location:1632 → 1670
    AWS; AWS domain
    pfam17982
    Location:1892 → 1941
    C5HCH; NSD Cys-His rich domain

  20. XM_036157909.1 → XP_036013802.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X3

    UniProtKB/TrEMBL
    A0A286YE36
    Conserved Domains (11) summary
    cd05838
    Location:1370 → 1464
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    PHA03307
    Location:1870 → 2191
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5034
    Location:1068 → 1202
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15648
    Location:1161 → 1202
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1208 → 1254
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1255 → 1308
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1325 → 1364
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:1736 → 1778
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd19210
    Location:1557 → 1698
    SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
    pfam17907
    Location:1517 → 1555
    AWS; AWS domain
    pfam17982
    Location:1777 → 1826
    C5HCH; NSD Cys-His rich domain

  21. XM_006517142.5 → XP_006517205.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

    See identical proteins and their annotated locations for XP_006517205.1

    UniProtKB/TrEMBL
    A0A286YE36, E9QAE4
    Conserved Domains (12) summary
    cd05837
    Location:320 → 430
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:1755 → 1849
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    PHA03307
    Location:2255 → 2576
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5034
    Location:1453 → 1587
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15648
    Location:1546 → 1587
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1593 → 1639
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1640 → 1693
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1710 → 1749
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:2121 → 2163
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    pfam17907
    Location:1902 → 1940
    AWS; AWS domain
    pfam17982
    Location:2162 → 2211
    C5HCH; NSD Cys-His rich domain
    cd19210
    Location:1942 → 2083
    SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins

  22. XM_006517141.3 → XP_006517204.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1

    See identical proteins and their annotated locations for XP_006517204.1

    UniProtKB/TrEMBL
    A0A286YE36, E9QAE4
    Conserved Domains (12) summary
    cd05837
    Location:320 → 430
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:1755 → 1849
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    PHA03307
    Location:2255 → 2576
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5034
    Location:1453 → 1587
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15648
    Location:1546 → 1587
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1593 → 1639
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1640 → 1693
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1710 → 1749
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:2121 → 2163
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    pfam17907
    Location:1902 → 1940
    AWS; AWS domain
    pfam17982
    Location:2162 → 2211
    C5HCH; NSD Cys-His rich domain
    cd19210
    Location:1942 → 2083
    SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins

  23. XM_036157905.1 → XP_036013798.1  histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X2

    UniProtKB/TrEMBL
    A0A286YE36
    Conserved Domains (12) summary
    cd05837
    Location:50 → 160
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:1485 → 1579
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    PHA03307
    Location:1985 → 2306
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5034
    Location:1183 → 1317
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15648
    Location:1276 → 1317
    PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2
    cd15650
    Location:1323 → 1369
    PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15653
    Location:1370 → 1423
    PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15656
    Location:1440 → 1479
    PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd15659
    Location:1851 → 1893
    PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
    cd19210
    Location:1672 → 1813
    SET_NSD1; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins
    pfam17907
    Location:1632 → 1670
    AWS; AWS domain
    pfam17982
    Location:1892 → 1941
    C5HCH; NSD Cys-His rich domain

RNA

  1. XR_382424.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88491.1 GenPept UniProtKB/Swiss-Prot:O88491

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