B0464.9 putative protein phosphatase methylesterase 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: B0464.9
Official Full Name: putative protein phosphatase methylesterase 1
Primary source: WormBase:WBGene00007188
Locus tag: CELE_B0464.9
See related: AllianceGenome:WB:WBGene00007188
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein C-terminal methylesterase activity and protein phosphatase 2A binding activity. Predicted to be involved in protein demethylation. Orthologous to human PPME1 (protein phosphatase methylesterase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See B0464.9 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 5

Sequence:: Chromosome: III; NC_003281.10 (9465767..9467148)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0464.7 (e-PCR)
- UniSTS:308859

B0464.6 (e-PCR)
- UniSTS:321167

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables protein C-terminal methylesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein C-terminal methylesterase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein methylesterase activity	IEA Inferred from Electronic Annotation more info
enables protein phosphatase 2A binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in protein demethylation	IEA Inferred from Electronic Annotation more info
involved_in protein demethylation	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: putative protein phosphatase methylesterase 1

NP_499084.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

9465767..9467148

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066683.6 → NP_499084.1 putative protein phosphatase methylesterase 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499084.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9BIB3

Conserved Domains (3) summary

COG0596
Location:68 → 337

MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

pfam12695
Location:89 → 190

Abhydrolase_5; Alpha/beta hydrolase family

cl00400
Location:49 → 89

Fe-S_biosyn; Iron-sulphur cluster biosynthesis