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ser-2 G-protein coupled receptors family 1 profile domain-containing protein;Tyramine receptor Ser-2 [ Caenorhabditis elegans ]

Gene ID: 182110, updated on 2-Nov-2024

Summary

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Official Symbol
ser-2
Official Full Name
G-protein coupled receptors family 1 profile domain-containing protein;Tyramine receptor Ser-2
Primary source
WormBase:WBGene00004777
Locus tag
CELE_C02D4.2
See related
AllianceGenome:WB:WBGene00004777
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables tyramine receptor activity. Involved in octopamine or tyramine signaling pathway. Located in plasma membrane. Is expressed in body wall musculature; excretory gland cell; neurons; non-striated muscle; and uterine toroidal epithelial cell. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ser-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
14
Sequence:
Chromosome: X; NC_003284.9 (15286533..15302963, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Ile Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tyramine receptor (SER-2) isoforms are involved in the regulation of pharyngeal pumping and foraging behavior in Caenorhabditis elegans. Rex E, et al. J Neurochem, 2004 Dec. PMID 15569254
  2. Characterization of a tyramine receptor from Caenorhabditis elegans. Rex E, et al. J Neurochem, 2002 Sep. PMID 12354282
  3. Role of tyramine in calcium dynamics of GABAergic neurons and escape behavior in Caenorhabditis elegans. Kagawa-Nagamura Y, et al. Zoological Lett, 2018. PMID 30065850, Free PMC Article
  4. Distinct Circuits for the Formation and Retrieval of an Imprinted Olfactory Memory. Jin X, et al. Cell, 2016 Feb 11. PMID 26871629, Free PMC Article
  5. Nematicidal activity of two monoterpenoids and SER-2 tyramine receptor of Caenorhabditis elegans. Lei J, et al. Biochem Pharmacol, 2010 Apr 1. PMID 19896925

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tyramine receptor (SER-2) isoforms are involved in the regulation of pharyngeal pumping and foraging behavior in Caenorhabditis elegans.
    Title: Tyramine receptor (SER-2) isoforms are involved in the regulation of pharyngeal pumping and foraging behavior in Caenorhabditis elegans.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables G protein-coupled amine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables octopamine receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables tyramine receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled dopamine receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in octopamine or tyramine signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to stimulus IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
G-protein coupled receptors family 1 profile domain-containing protein;Tyramine receptor Ser-2
NP_001024335.1
  • Confirmed by transcript evidence
NP_001024336.1
  • Confirmed by transcript evidence
NP_001024337.1
  • Partially confirmed by transcript evidence
NP_001024338.1
  • Partially confirmed by transcript evidence
NP_001024339.1
  • Confirmed by transcript evidence
NP_001024340.1
  • Confirmed by transcript evidence
NP_001257260.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    15286533..15302963 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029165.5 → NP_001024336.1  Tyramine receptor Ser-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024336.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3IUK5
    Conserved Domains (1) summary
    pfam00001
    Location:71 → 397
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  2. NM_001029164.3 → NP_001024335.1  Tyramine receptor Ser-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024335.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3IUK5
    Conserved Domains (1) summary
    pfam00001
    Location:74 → 400
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  3. NM_001270331.4 → NP_001257260.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257260.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3IUK5, H2FLI4
    Conserved Domains (1) summary
    cd15060
    Location:58 → 399
    7tmA_tyramine_octopamine_R-like; tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. NM_001029168.4 → NP_001024339.1  Tyramine receptor Ser-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024339.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O02213, Q6LA87, Q6LA88, Q6LA89, Q6LA90
    UniProtKB/TrEMBL
    D3IUK5
    Conserved Domains (1) summary
    pfam00001
    Location:74 → 423
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  5. NM_001029169.5 → NP_001024340.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024340.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3IUK5, G5EF04
    Conserved Domains (1) summary
    cd15060
    Location:47 → 400
    7tmA_tyramine_octopamine_R-like; tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors

  6. NM_001029167.1 → NP_001024338.1  Tyramine receptor Ser-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024338.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O02213
    Conserved Domains (1) summary
    pfam00001
    Location:68 → 173
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  7. NM_001029166.1 → NP_001024337.1  Tyramine receptor Ser-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024337.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O02213
    Conserved Domains (1) summary
    pfam00001
    Location:71 → 176
    7tm_1; 7 transmembrane receptor (rhodopsin family)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O02213.4

Gene LinkOut

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