nhr-76 Nuclear hormone receptor family member nhr-76 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nhr-76
Official Full Name: Nuclear hormone receptor family member nhr-76
Primary source: WormBase:WBGene00015497
Locus tag: CELE_C05G6.1
See related: AllianceGenome:WB:WBGene00015497
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in positive regulation of fatty acid beta-oxidation by octopamine signaling pathway; positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including excretory gland cell; intestine; pharynx; seam cell; and vulval muscle. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nhr-76 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 9

Sequence:: Chromosome: IV; NC_003282.8 (627537..633963)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C05G6.1 (e-PCR)
- UniSTS:319002

C05G6.2 (e-PCR)
- UniSTS:319990

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fatty acid beta-oxidation by octopamine signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nuclear hormone receptor family member nhr-76

NP_499961.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

627537..633963

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067560.6 → NP_499961.2 Nuclear hormone receptor family member nhr-76 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499961.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q65CM0

Conserved Domains (2) summary

smart00399
Location:78 → 151

ZnF_C4; c4 zinc finger in nuclear hormone receptors

smart00430
Location:266 → 428

HOLI; Ligand binding domain of hormone receptors