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ints-1 Integrator complex subunit 1 RPB2-binding domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 182280, updated on 2-Nov-2024

Summary

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Official Symbol
ints-1
Official Full Name
Integrator complex subunit 1 RPB2-binding domain-containing protein
Primary source
WormBase:WBGene00015499
Locus tag
CELE_C06A5.1
See related
AllianceGenome:WB:WBGene00015499
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in U2 snRNA 3'-end processing. Predicted to be part of integrator complex. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with cataracts, poor growth, and dysmorphic facies. Orthologous to human INTS1 (integrator complex subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ints-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
19
Sequence:
Chromosome: I; NC_003279.8 (6011977..6022666)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene RING-type domain-containing protein Neighboring gene RING-type domain-containing protein Neighboring gene ncRNA Neighboring gene COP9 signalosome complex subunit 2 Neighboring gene ncRNA Neighboring gene DUF4044 domain-containing protein Neighboring gene Chromatin modification-related protein MEAF6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Disruption of the Caenorhabditis elegans Integrator complex triggers a non-conventional transcriptional mechanism beyond snRNA genes. Gómez-Orte E, et al. PLoS Genet, 2019 Feb. PMID 30807579, Free PMC Article
  2. Systematic transcriptome analysis associated with physiological and chronological aging in Caenorhabditis elegans. Ham S, et al. Genome Res, 2022 Nov-Dec. PMID 36351769, Free PMC Article
  3. Alignment of the genetic and physical maps in the dpy-5 bli-4 (I) region of C. elegans by the serial cosmid rescue of lethal mutations. McDowall JS, et al. Mol Gen Genet, 1997 Jun. PMID 9230901
  4. Genetic analysis of sterile mutants in the dpy-5 unc-13 (I) genomic region of Caenorhabditis elegans. McDowall JS, et al. Mol Gen Genet, 1997 Jun. PMID 9230900
  5. Allelic ratios and the mutational landscape reveal biologically significant heterozygous SNVs. Chu JS, et al. Genetics, 2012 Apr. PMID 22267497, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in U2 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in U2 snRNA 3'-end processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrator complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Integrator complex subunit 1 RPB2-binding domain-containing protein
NP_491739.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    6011977..6022666
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059338.3 → NP_491739.2  Integrator complex subunit 1 RPB2-binding domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491739.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O01483
    Conserved Domains (1) summary
    pfam12432
    Location:308 → 392
    DUF3677; Protein of unknown function (DUF3677)
Nucleotide Protein
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Gene LinkOut

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