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stdh-1 Putative steroid dehydrogenase 1 [ Caenorhabditis elegans ]

Gene ID: 182291, updated on 2-Nov-2024

Summary

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Official Symbol
stdh-1
Official Full Name
Putative steroid dehydrogenase 1
Primary source
WormBase:WBGene00007363
Locus tag
CELE_C06B3.4
See related
AllianceGenome:WB:WBGene00007363
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable oxidoreductase activity. Predicted to be involved in fatty acid elongation. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including body wall musculature; intestine; muscle cell; nervous system; and tail. Human ortholog(s) of this gene implicated in 17-beta hydroxysteroid dehydrogenase 3 deficiency and disorder of sexual development. Orthologous to several human genes including HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See stdh-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (13906492..13908037)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Seven TM Receptor Neighboring gene Putative steroid dehydrogenase 3 Neighboring gene DUF3444 domain-containing protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bacterial vitamin B(12) production enhances nematode predatory behavior. Akduman N, et al. ISME J, 2020 Jun. PMID 32152389, Free PMC Article
  2. Diacetyl odor shortens longevity conferred by food deprivation in C. elegans via downregulation of DAF-16/FOXO. Park S, et al. Aging Cell, 2021 Jan. PMID 33382195, Free PMC Article
  3. Distinct activities of the germline and somatic reproductive tissues in the regulation of Caenorhabditis elegans' longevity. Yamawaki TM, et al. Genetics, 2008 Jan. PMID 18202391, Free PMC Article
  4. A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. Hansen M, et al. PLoS Genet, 2008 Feb. PMID 18282106, Free PMC Article
  5. Hexosamine pathway metabolites enhance protein quality control and prolong life. Denzel MS, et al. Cell, 2014 Mar 13. PMID 24630720

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Putative steroid dehydrogenase 1
NP_506449.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    13906492..13908037
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_074048.4 → NP_506449.1  Putative steroid dehydrogenase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506449.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q17703
    Conserved Domains (2) summary
    cd05356
    Location:47 → 289
    17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs
    pfam00106
    Location:49 → 242
    adh_short; short chain dehydrogenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q17703.1

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