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stdh-3 Putative steroid dehydrogenase 3 [ Caenorhabditis elegans ]

Gene ID: 182292, updated on 2-Nov-2024

Summary

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Official Symbol
stdh-3
Official Full Name
Putative steroid dehydrogenase 3
Primary source
WormBase:WBGene00007364
Locus tag
CELE_C06B3.5
See related
AllianceGenome:WB:WBGene00007364
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable oxidoreductase activity. Predicted to be involved in fatty acid elongation. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in 17-beta hydroxysteroid dehydrogenase 3 deficiency and disorder of sexual development. Orthologous to several human genes including HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See stdh-3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (13904611..13905996)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Nose resistant-to-fluoxetine protein N-terminal domain-containing protein Neighboring gene Seven TM Receptor Neighboring gene Putative steroid dehydrogenase 1 Neighboring gene DUF3444 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Antioxidant and reducing lipid accumulation effects of rutin in Caenorhabditis elegans. Qin X, et al. Biofactors, 2021 Jul. PMID 33988888
  2. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Putative steroid dehydrogenase 3
NP_506448.2
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    13904611..13905996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_074047.4 → NP_506448.2  Putative steroid dehydrogenase 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506448.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q17704
    Conserved Domains (2) summary
    PLN02780
    Location:13 → 312
    PLN02780; ketoreductase/ oxidoreductase
    cd05356
    Location:47 → 287
    17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q17704.2

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