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nas-7 Zinc metalloproteinase nas-7 [ Caenorhabditis elegans ]

Gene ID: 182368, updated on 2-Nov-2024

Summary

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Official Symbol
nas-7
Official Full Name
Zinc metalloproteinase nas-7
Primary source
WormBase:WBGene00003526
Locus tag
CELE_C07D10.4
See related
AllianceGenome:WB:WBGene00003526
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metalloendopeptidase activity. Involved in nematode pharyngeal pumping and pharynx development. Predicted to be located in extracellular region. Is expressed in several structures, including arcade cell; hypodermis; pharynx; spermatheca; and vulva. Orthologous to human ASTL (astacin like metalloendopeptidase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nas-7 in Genome Data Viewer
Location:
chromosome: II
Exon count:
9
Sequence:
Chromosome: II; NC_003280.10 (7400545..7402725, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class E (Epsilon) Neighboring gene BTB domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene Serpentine receptor class delta-55 Neighboring gene Uncharacterized protein Neighboring gene Amino acid permease;Potassium/chloride cotransporter 3 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the astacin family of metalloproteases in C. elegans. Park JO, et al. BMC Dev Biol, 2010 Jan 28. PMID 20109220, Free PMC Article
  2. Improvement of Locomotion Caused by Lactococcus lactis subsp. lactis in the Model Organism Caenorhabditis elegans. Ali MS, et al. Nutrients, 2023 Oct 23. PMID 37892557, Free PMC Article
  3. The astacin protein family in Caenorhabditis elegans. Möhrlen F, et al. Eur J Biochem, 2003 Dec. PMID 14653817
  4. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nematode pharyngeal pumping IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in pharynx development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Zinc metalloproteinase nas-7
NP_495552.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    7400545..7402725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063151.4 → NP_495552.2  Zinc metalloproteinase nas-7 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495552.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P55113, Q7Z0N5
    Conserved Domains (3) summary
    cd04280
    Location:91 → 270
    ZnMc_astacin_like; Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to ...
    pfam01400
    Location:87 → 274
    Astacin; Astacin (Peptidase family M12A)
    pfam01549
    Location:347 → 382
    ShK; ShK domain-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P55113.2

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