svh-1 Serine protease svh-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: svh-1
Official Full Name: Serine protease svh-1
Primary source: WormBase:WBGene00006620
Locus tag: CELE_C07G1.1
See related: AllianceGenome:WB:WBGene00006620
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable serine-type endopeptidase activity. Involved in several processes, including positive regulation of gonad development; positive regulation of nematode pharyngeal pumping; and protein destabilization. Predicted to be located in extracellular space. Is expressed in ADLL and ADLR. Human ortholog(s) of this gene implicated in enterokinase deficiency. Orthologous to human TMPRSS15 (transmembrane serine protease 15). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See svh-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 16

Sequence:: Chromosome: IV; NC_003282.8 (8206614..8213741)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SVH-1 acts as both a growth factor and a protease in C. elegans.
Title: The C. elegans HGF/plasminogen-like protein SVH-1 has protease-dependent and -independent functions.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C07G1.1 (e-PCR)
- UniSTS:308506

C07G1.6 (e-PCR)
- UniSTS:315447

C07G1.7 (e-PCR)
- UniSTS:315448

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon regeneration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nematode pharyngeal pumping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Serine protease svh-1

NP_501379.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

8206614..8213741

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068978.6 → NP_501379.2 Serine protease svh-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501379.2

Status: REVIEWED

UniProtKB/Swiss-Prot

H1AGA0, Q17800

Conserved Domains (6) summary

smart00192
Location:558 → 590

LDLa; Low-density lipoprotein receptor domain class A

smart00130
Location:227 → 306

KR; Kringle domain

cd00112
Location:320 → 355

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd00190
Location:713 → 945

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

cd01099
Location:373 → 434

PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...

cl02509
Location:599 → 681

SRCR_2; Scavenger receptor cysteine-rich domain