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rap-3 RAP homolog (vertebrate Rap GTPase family) [ Caenorhabditis elegans ]

Gene ID: 182417, updated on 2-Nov-2024

Summary

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Official Symbol
rap-3
Official Full Name
RAP homolog (vertebrate Rap GTPase family)
Primary source
WormBase:WBGene00004309
Locus tag
CELE_C08F8.7
See related
AllianceGenome:WB:WBGene00004309
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Rap protein signal transduction and negative regulation of cell migration. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in pharynx. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rap-3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
5
Sequence:
Chromosome: IV; NC_003282.8 (11177267..11178241)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Nuclear hormone receptor family member nhr-67 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Calponin-homology (CH) domain-containing protein;Choline/carnitine acyltransferase domain-containing protein Neighboring gene Peroxisomal membrane protein PEX14 Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. α-Integrins dictate distinct modes of type IV collagen recruitment to basement membranes. Jayadev R, et al. J Cell Biol, 2019 Sep 2. PMID 31387941, Free PMC Article
  2. Small GTPases. Lundquist EA. WormBook, 2006 Jan 17. PMID 18050472, Free PMC Article
  3. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Rap protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RAP homolog (vertebrate Rap GTPase family)
NP_502095.2
  • Product from WormBase gene class rap;
    Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    11177267..11178241
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069694.4 → NP_502095.2  RAP homolog (vertebrate Rap GTPase family) [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502095.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O01312
    Conserved Domains (2) summary
    smart00010
    Location:2 → 166
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
    cd00876
    Location:5 → 158
    Ras; Rat sarcoma (Ras) family of small guanosine triphosphatases (GTPases)
Nucleotide Protein
Heading Accession and Version

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