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mnm-2 Zinc finger protein mnm-2 [ Caenorhabditis elegans ]

Gene ID: 182489, updated on 2-Nov-2024

Summary

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Official Symbol
mnm-2
Official Full Name
Zinc finger protein mnm-2
Primary source
WormBase:WBGene00003380
Locus tag
CELE_C10A4.8
See related
AllianceGenome:WB:WBGene00003380
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of axon guidance. Located in nucleus. Is expressed in several structures, including intestine; neurons; rectum; spermathecal-uterine junction; and vulva. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mnm-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
6
Sequence:
Chromosome: X; NC_003284.9 (7422641..7424913, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Transmembrane protein Neighboring gene HAT C-terminal dimerization domain-containing protein Neighboring gene Epithelial membrane protein 2;Inner membrane protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The C. elegans M3 neuron guides the growth cone of its sister cell M2 via the Krüppel-like zinc finger protein MNM-2. Rauthan M, et al. Dev Biol, 2007 Nov 1. PMID 17916347
  2. A genetic analysis of axon guidance in the C elegans pharynx. Mörck C, et al. Dev Biol, 2003 Aug 1. PMID 12885562
  3. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Zinc finger protein mnm-2
NP_509256.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    7422641..7424913 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076855.5 → NP_509256.2  Zinc finger protein mnm-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509256.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q17895
    Conserved Domains (3) summary
    sd00017
    Location:170 → 190
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:224 → 246
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:183 → 207
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q17895.2

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