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npr-3 Neuropeptide receptor 3 [ Caenorhabditis elegans ]

Gene ID: 182494, updated on 2-Nov-2024

Summary

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Official Symbol
npr-3
Official Full Name
Neuropeptide receptor 3
Primary source
WormBase:WBGene00007006
Locus tag
CELE_C10C6.2
See related
AllianceGenome:WB:WBGene00007006
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable G protein-coupled photoreceptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; cellular response to light stimulus; and phototransduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in ventral cord neurons. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human PRLHR (prolactin releasing hormone receptor). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See npr-3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
7
Sequence:
Chromosome: IV; NC_003282.8 (11459984..11463199)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene PH-15 domain-containing protein Neighboring gene Transmembrane protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Inactivity periods and postural change speed can explain atypical postural change patterns of Caenorhabditis elegans mutants. Fukunaga T, et al. BMC Bioinformatics, 2017 Jan 19. PMID 28103804, Free PMC Article
  2. Functional annotation of the putative orphan Caenorhabditis elegans G-protein-coupled receptor C10C6.2 as a FLP15 peptide receptor. Kubiak TM, et al. J Biol Chem, 2003 Oct 24. PMID 12937167
  3. BLIMP-1/BLMP-1 and Metastasis-Associated Protein Regulate Stress Resistant Development in Caenorhabditis elegans. Hyun M, et al. Genetics, 2016 Aug. PMID 27334271, Free PMC Article
  4. Whole-genome analysis of 60 G protein-coupled receptors in Caenorhabditis elegans by gene knockout with RNAi. Keating CD, et al. Curr Biol, 2003 Sep 30. PMID 14521838
  5. Pharmacological and functional similarities of the human neuropeptide Y system in C. elegans challenges phylogenetic views on the FLP/NPR system. Gershkovich MM, et al. Cell Commun Signal, 2019 Sep 18. PMID 31533726, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. cloning and functional annotation of a C10C6.2 as a receptor for the FMRFamide-related peptides (FaRPs) encoded on the flp15 precursor gene, leading to the receptor designation FLP15-R
    Title: Functional annotation of the putative orphan Caenorhabditis elegans G-protein-coupled receptor C10C6.2 as a FLP15 peptide receptor.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables G protein-coupled photoreceptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to light stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in detection of visible light IEA
Inferred from Electronic Annotation
more info
  
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in phototransduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Neuropeptide receptor 3
NP_502162.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    11459984..11463199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069761.4 → NP_502162.1  Neuropeptide receptor 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502162.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P90745
    Conserved Domains (1) summary
    cd15203
    Location:26 → 314
    7tmA_NPYR-like; neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein
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