hrg-7 Aspartic protease 10 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hrg-7
Official Full Name: Aspartic protease 10
Primary source: WormBase:WBGene00007605
Locus tag: CELE_C15C8.3
See related: AllianceGenome:WB:WBGene00007605
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in apoptotic process and proteolysis. Predicted to be located in extracellular region. Predicted to be active in lysosome. Is expressed in amphid neurons; intestine; and phasmid neurons. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hrg-7 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 7

Sequence:: Chromosome: V; NC_003283.11 (12742041..12744171)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C15C8.3 (e-PCR)
- UniSTS:321225

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables aspartic-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aspartic-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Aspartic protease 10

NP_001256448.1

Partially confirmed by transcript evidence

NP_001256449.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

12742041..12744171

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001269519.3 → NP_001256448.1 Aspartic protease 10 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256448.1

Status: REVIEWED

UniProtKB/Swiss-Prot

E0AHB8, Q18020

Conserved Domains (1) summary

cl11403
Location:71 → 427

pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases
NM_001269520.3 → NP_001256449.1 Aspartic protease 10 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256449.1

Status: REVIEWED

UniProtKB/TrEMBL

E0AHB8

Conserved Domains (1) summary

pfam00026
Location:1 → 188

Asp; Eukaryotic aspartyl protease