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nkb-1 Sodium/potassium-transporting ATPase subunit beta-1 [ Caenorhabditis elegans ]

Gene ID: 182726, updated on 2-Nov-2024

Summary

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Official Symbol
nkb-1
Official Full Name
Sodium/potassium-transporting ATPase subunit beta-1
Primary source
WormBase:WBGene00007646
Locus tag
CELE_C17E4.9
See related
AllianceGenome:WB:WBGene00007646
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATPase activator activity. Predicted to be involved in intracellular monoatomic cation homeostasis and monoatomic cation transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of sodium:potassium-exchanging ATPase complex. Is expressed in intestine; neurons; and non-striated muscle. Human ortholog(s) of this gene implicated in atrophic gastritis; autoimmune gastritis; essential hypertension; and stomach cancer. Orthologous to several human genes including ATP1B4 (ATPase Na+/K+ transporting family member beta 4); ATP1B1 (ATPase Na+/K+ transporting subunit beta 1); and ATP1B2 (ATPase Na+/K+ transporting subunit beta 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nkb-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003279.8 (9431249..9433828)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Vacuolar protein sorting-associated protein 72 homolog Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene PRKC apoptosis WT1 regulator protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Na+/K+ ATPase regulates the expression and localization of acetylcholine receptors in a pump activity-independent manner. Doi M, et al. Mol Cell Neurosci, 2008 Aug. PMID 18599311, Free PMC Article
  2. Galectin LEC-1 plays a defensive role against damage due to oxidative stress in Caenorhabditis elegans. Takeuchi T, et al. J Biochem, 2013 Nov. PMID 23935187
  3. Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi. Simmer F, et al. Curr Biol, 2002 Aug 6. PMID 12176360
  4. Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states. Tan D, et al. Elife, 2016 Mar 8. PMID 26952210, Free PMC Article
  5. SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells. Jackson J, et al. Mol Metab, 2022 Jul. PMID 35452878, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular potassium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular sodium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion export across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of sodium:potassium-exchanging ATPase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of sodium:potassium-exchanging ATPase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Sodium/potassium-transporting ATPase subunit beta-1
NP_492506.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    9431249..9433828
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060105.8 → NP_492506.1  Sodium/potassium-transporting ATPase subunit beta-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492506.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q93235
    Conserved Domains (1) summary
    pfam00287
    Location:27 → 303
    Na_K-ATPase; Sodium / potassium ATPase beta chain

RNA

  1. NR_136361.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q93235.1

Gene LinkOut

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