U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

fkh-10 Fork-head domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 182874, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
fkh-10
Official Full Name
Fork-head domain-containing protein
Primary source
WormBase:WBGene00001442
Locus tag
CELE_C25A1.2
See related
AllianceGenome:WB:WBGene00001442
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in gonad; head ganglion; head neurons; and pharyngeal neurons. Orthologous to human FOXL3-OT1 (FOXL3 overlapping transcript 1) and FOXL3 (forkhead box L3). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See fkh-10 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003279.8 (10163475..10165132, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene TPX2 domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene mRNA cap guanine-N7 methyltransferase Neighboring gene FAM192A/Fyv6 N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene RRM domain-containing protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Synthetic lethal interactions identify phenotypic "interologs" of the spindle assembly checkpoint components. Tarailo M, et al. Genetics, 2007 Dec. PMID 18073444, Free PMC Article
  2. The forkhead gene family of Caenorhabditis elegans. Hope IA, et al. Gene, 2003 Jan 30. PMID 12568714
  3. PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Panowski SH, et al. Nature, 2007 May 31. PMID 17476212
  4. A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis. Ma X, et al. Nat Methods, 2021 Aug. PMID 34312566
  5. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Fork-head domain-containing protein
NP_492676.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    10163475..10165132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060275.7 → NP_492676.2  Fork-head domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492676.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O17593
    Conserved Domains (1) summary
    pfam00250
    Location:41 → 125
    Forkhead; Forkhead domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools