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gba-2 Putative glucosylceramidase 2 [ Caenorhabditis elegans ]

Gene ID: 183155, updated on 2-Nov-2024

Summary

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Official Symbol
gba-2
Official Full Name
Putative glucosylceramidase 2
Primary source
WormBase:WBGene00016340
Locus tag
CELE_C33C12.8
See related
AllianceGenome:WB:WBGene00016340
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable glucosylceramidase activity. Predicted to be involved in glucosylceramide catabolic process. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gba-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
10
Sequence:
Chromosome: II; NC_003280.10 (2182494..2186434, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene AMP-binding_C domain-containing protein Neighboring gene Putative glucosylceramidase 1 Neighboring gene Methyltransferase small domain-containing protein Neighboring gene Membralin;TMV resistance protein N-like Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Degradation of hexosylceramides is required for timely corpse clearance via formation of cargo-containing phagolysosomal vesicles. Holzapfel R, et al. Eur J Cell Biol, 2024 Jun. PMID 38582051
  2. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Sun Y, et al. Elife, 2020 Jun 2. PMID 32482227, Free PMC Article
  3. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  4. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article
  5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables glucosylceramidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucosylceramidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glucosylceramide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Putative glucosylceramidase 2
NP_494208.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    2182494..2186434 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_061807.7 → NP_494208.2  Putative glucosylceramidase 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_494208.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O16581
    Conserved Domains (2) summary
    pfam02055
    Location:98 → 443
    Glyco_hydro_30; Glycosyl hydrolase family 30 TIM-barrel domain
    pfam17189
    Location:446 → 512
    Glyco_hydro_30C; Glycosyl hydrolase family 30 beta sandwich domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O16581.2

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