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nex-4 Annexin [ Caenorhabditis elegans ]

Gene ID: 183294, updated on 2-Nov-2024

Summary

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Official Symbol
nex-4
Official Full Name
Annexin
Primary source
WormBase:WBGene00003591
Locus tag
CELE_C37H5.1
See related
AllianceGenome:WB:WBGene00003591
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable calcium-dependent phospholipid binding activity and phosphatidylserine binding activity. Predicted to be active in several cellular components, including nucleus; plasma membrane; and vesicle membrane. Is expressed in intestine and nervous system. Orthologous to human ANXA10 (annexin A10); ANXA8 (annexin A8); and ANXA9 (annexin A9). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nex-4 in Genome Data Viewer
Location:
chromosome: V
Exon count:
9
Sequence:
Chromosome: V; NC_003283.11 (4851472..4857276)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Abhydrolase domain-containing protein abhd-5.2 Neighboring gene Abhydrolase domain-containing protein abhd-5.1 Neighboring gene Acetyltransferase;Acyl-coenzyme A thioesterase 8;RRM_2 domain-containing protein Neighboring gene Serpentine receptor class delta-32 Neighboring gene Serpentine receptor class delta-33 Neighboring gene Gamma-glutamyltranspeptidase 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ligand-binding activity and expression profile of annexins in Caenorhabditis elegans. Nishioka S, et al. J Biochem, 2007 Jan. PMID 17169974
  2. Transcription, biochemistry and localization of nematode annexins. Daigle SN, et al. J Cell Sci, 1999 Jun. PMID 10341209
  3. Expanded genetic screening in Caenorhabditis elegans identifies new regulators and an inhibitory role for NAD(+) in axon regeneration. Kim KW, et al. Elife, 2018 Nov 21. PMID 30461420, Free PMC Article
  4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Annexin
NP_001309625.1
  • Confirmed by transcript evidence
NP_001368593.1
  • Confirmed by transcript evidence
NP_001379788.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    4851472..4857276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001322553.3 → NP_001309625.1  Annexin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MB16
    Conserved Domains (1) summary
    pfam00191
    Location:305 → 370
    Annexin; Annexin

  2. NM_001380638.1 → NP_001368593.1  Annexin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MBL3
    Conserved Domains (1) summary
    pfam00191
    Location:319 → 384
    Annexin

  3. NM_001392506.1 → NP_001379788.1  Annexin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    P91144
    Conserved Domains (1) summary
    pfam00191
    Location:266 → 331
    Annexin
Nucleotide Protein
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