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set-32 SET domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 183391, updated on 18-Sep-2024

Summary

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Official Symbol
set-32
Official Full Name
SET domain-containing protein
Primary source
WormBase:WBGene00008062
Locus tag
CELE_C41G7.4
See related
AllianceGenome:WB:WBGene00008062
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Is expressed in germ line. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See set-32 in Genome Data Viewer
Location:
chromosome: I
Exon count:
7
Sequence:
Chromosome: I; NC_003279.8 (9519244..9521275)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Messenger RNA-binding inhibitor of apoptosis 1 Neighboring gene ncRNA Neighboring gene Aryl hydrocarbon receptor protein 1 Neighboring gene ncRNA Neighboring gene Lipoprotein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caenorhabditis elegans nuclear RNAi factor SET-32 deposits the transgenerational histone modification, H3K23me3. Schwartz-Orbach L, et al. Elife, 2020 Aug 17. PMID 32804637, Free PMC Article
  2. Chromatin Modifiers SET-25 and SET-32 Are Required for Establishment but Not Long-Term Maintenance of Transgenerational Epigenetic Inheritance. Woodhouse RM, et al. Cell Rep, 2018 Nov 20. PMID 30463020
  3. Natural cryptic variation in epigenetic modulation of an embryonic gene regulatory network. Ewe CK, et al. Proc Natl Acad Sci U S A, 2020 Jun 16. PMID 32482879, Free PMC Article
  4. H3K9me3 is required for inheritance of small RNAs that target a unique subset of newly evolved genes. Lev I, et al. Elife, 2019 Mar 14. PMID 30869075, Free PMC Article
  5. The spatial and temporal dynamics of nuclear RNAi-targeted retrotransposon transcripts in Caenorhabditis elegans. Ni JZ, et al. Development, 2018 Oct 22. PMID 30254142, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Caenorhabditis elegans nuclear RNAi factor SET-32 deposits the transgenerational histone modification, H3K23me3.
    Title: Caenorhabditis elegans nuclear RNAi factor SET-32 deposits the transgenerational histone modification, H3K23me3.
  2. silencing establishment at the endogenous targets of germline nuclear RNAi also requires SET-32.
    Title: C. elegans Heterochromatin Factor SET-32 Plays an Essential Role in Transgenerational Establishment of Nuclear RNAi-Mediated Epigenetic Silencing.
  3. the putative histone methyltransferases SET-25 and SET-32 are required for establishment of a transgenerational silencing signal but not for long-term maintenance of this signal between subsequent generations
    Title: Chromatin Modifiers SET-25 and SET-32 Are Required for Establishment but Not Long-Term Maintenance of Transgenerational Epigenetic Inheritance.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables histone H3 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SET domain-containing protein
NP_492529.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    9519244..9521275
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060128.3 → NP_492529.2  SET domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492529.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q93368
    Conserved Domains (1) summary
    smart00317
    Location:307 → 455
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
Nucleotide Protein
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