hnd-1 Hand transcription factor 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hnd-1
Official Full Name: Hand transcription factor 1
Primary source: WormBase:WBGene00001981
Locus tag: CELE_C44C10.8
See related: AllianceGenome:WB:WBGene00001981
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in gonad development. Acts upstream of or within gonadal mesoderm development and positive regulation of muscle cell differentiation. Predicted to be located in nucleus. Is expressed in several structures, including Da; Daa; Dap; pharynx; and somatic gonad precursor. Orthologous to human HAND1 (heart and neural crest derivatives expressed 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hnd-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 4

Sequence:: Chromosome: X; NC_003284.9 (11684561..11685788)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings show that in addition to HLH-1, UNC-120/SRF and HND-1/HAND, can convert naive blastomeres to muscle when overproduced ectopically in the embryo; both of these factors act in concert with HLH-1 to regulate myogenesis
Title: Defining the transcriptional redundancy of early bodywall muscle development in C. elegans: evidence for a unified theory of animal muscle development.
affects the presence and position of both the somatic gonadal precursors and primordial germ cells within the primordium, but does not appear to have any role in later gonadogenesis
Title: The C. elegans Hand gene controls embryogenesis and early gonadogenesis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C44C10.8 (e-PCR)
- UniSTS:316372

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in developmental process	IBA Inferred from Biological aspect of Ancestor more info
involved_in gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gonadal mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle organ development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of muscle cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Hand transcription factor 1

NP_509952.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

11684561..11685788

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077551.4 → NP_509952.1 Hand transcription factor 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509952.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q18612

Conserved Domains (1) summary

cd11418
Location:24 → 81

bHLH_TS_ASCL; basic helix-loop-helix (bHLH) domain found in achaete-scute complex-like (ASCL) family