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ilys-2 Invertebrate-type lysozyme 2 [ Caenorhabditis elegans ]

Gene ID: 183475, updated on 2-Nov-2024

Summary

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Official Symbol
ilys-2
Official Full Name
Invertebrate-type lysozyme 2
Primary source
WormBase:WBGene00016669
Locus tag
CELE_C45G7.2
See related
AllianceGenome:WB:WBGene00016669
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable lysozyme activity. Involved in defense response to Gram-positive bacterium. Is expressed in intestine; nerve ring; and pm3. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ilys-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (2467678..2468879)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Cadherin domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Invertebrate-type lysozyme 3 Neighboring gene lysozyme Neighboring gene Ground-like domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mechanism of biofilm-mediated stress resistance and lifespan extension in C. elegans. Smolentseva O, et al. Sci Rep, 2017 Aug 2. PMID 28769037, Free PMC Article
  2. GH18 family glycoside hydrolase Chitinase A of Salmonella enhances virulence by facilitating invasion and modulating host immune responses. Chandra K, et al. PLoS Pathog, 2022 Apr. PMID 35482710, Free PMC Article
  3. Impaired immune response and barrier function in GSPD-1-deficient C. elegans infected with Klebsiella pneumoniae. Yang WH, et al. Curr Res Microb Sci, 2023. PMID 36798906, Free PMC Article
  4. Genomic clusters, putative pathogen recognition molecules, and antimicrobial genes are induced by infection of C. elegans with M. nematophilum. O'Rourke D, et al. Genome Res, 2006 Aug. PMID 16809667, Free PMC Article
  5. Diversification and adaptive sequence evolution of Caenorhabditis lysozymes (Nematoda: Rhabditidae). Schulenburg H, et al. BMC Evol Biol, 2008 Apr 19. PMID 18423043, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables lysozyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysozyme activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to Gram-positive bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in defense response to bacterium IEA
Inferred from Electronic Annotation
more info
  
involved_in killing of cells of another organism IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Invertebrate-type lysozyme 2
NP_500207.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    2467678..2468879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067806.3 → NP_500207.1  Invertebrate-type lysozyme 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500207.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O76358
    Conserved Domains (1) summary
    pfam05497
    Location:17 → 135
    Destabilase; Destabilase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O76358.1

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