djr-1.2 Glutathione-independent glyoxalase DJR-1.2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: djr-1.2
Official Full Name: Glutathione-independent glyoxalase DJR-1.2
Primary source: WormBase:WBGene00016789
Locus tag: CELE_C49G7.11
See related: AllianceGenome:WB:WBGene00016789
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable glyoxalase III activity. Involved in several processes, including cellular response to aldehyde; glyoxal metabolic process; and monocarboxylic acid biosynthetic process. Located in cytoplasm. Is expressed in several structures, including excretory cell; nervous system; pharynx; rectum; and reproductive system. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 7; Parkinsonism; cerebral infarction; and middle cerebral artery infarction. Orthologous to human PARK7 (Parkinsonism associated deglycase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See djr-1.2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 3

Sequence:: Chromosome: V; NC_003283.11 (4054074..4055125, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data demonstrate a novel role for the DJ-1 homologue, djr-1.2, in mitigating Manganese-dependent lifespan reduction and dopamine signaling alterations.
Title: Age- and manganese-dependent modulation of dopaminergic phenotypes in a C. elegans DJ-1 genetic model of Parkinson's disease.
Expression of DJR-1.2 is highly increased in the dauer stage.
Title: DJR-1.2 of Caenorhabditis elegans is induced by DAF-16 in the dauer state.
Sub-lethal doses of glyoxals caused significant degeneration of the dopaminergic neurons in C. elegans lacking cDJR-1.2.
Title: Human DJ-1 and its homologs are novel glyoxalases.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C49G7.11 (e-PCR)
- UniSTS:316398

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables glyoxalase III activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to glyoxal	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to methylglyoxal	IDA Inferred from Direct Assay more info	PubMed
involved_in glycolate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glyoxal metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glyoxal metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in lactate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in methylglyoxal catabolic process to lactate	IEA Inferred from Electronic Annotation more info
involved_in methylglyoxal metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Glutathione-independent glyoxalase DJR-1.2

NP_504132.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

4054074..4055125 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_071731.2 → NP_504132.1 Glutathione-independent glyoxalase DJR-1.2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_504132.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O16228

Conserved Domains (2) summary

TIGR01383
Location:6 → 181

not_thiJ; DJ-1 family protein

pfam01965
Location:5 → 167

DJ-1_PfpI; DJ-1/PfpI family