inpp-5K Inositol polyphosphate 5-phosphatase [Caenorhabditis elegans] - Gene

Summary

Official Symbol: inpp-5K
Official Full Name: Inositol polyphosphate 5-phosphatase
Primary source: WormBase:WBGene00086546
Locus tag: CELE_C50C3.7
See related: AllianceGenome:WB:WBGene00086546
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables phosphatidylinositol phosphate phosphatase activity. Acts upstream of or within with a positive effect on flagellated sperm motility. Located in several cellular components, including dendrite; neuronal cell body; and non-motile cilium. Is expressed in PVDL and PVDR. Human ortholog(s) of this gene implicated in congenital muscular dystrophy with cataracts and intellectual disability. Orthologous to human INPP5J (inositol polyphosphate-5-phosphatase J) and INPP5K (inositol polyphosphate-5-phosphatase K). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Membrane contact site-dependent cholesterol transport regulates Na(+)/K(+)-ATPase polarization and spermiogenesis in Caenorhabditis elegans.
Title: Membrane contact site-dependent cholesterol transport regulates Na(+)/K(+)-ATPase polarization and spermiogenesis in Caenorhabditis elegans.
The inositol 5-phosphatase INPP5K participates in the fine control of ER organization.
Title: The inositol 5-phosphatase INPP5K participates in the fine control of ER organization.
The CIL-1 PI 5-phosphatase localizes TRP Polycystins to cilia and activates sperm in C. elegans.
Title: The CIL-1 PI 5-phosphatase localizes TRP Polycystins to cilia and activates sperm in C. elegans.

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Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol phosphate phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in fertilization	IC Inferred by Curator more info	PubMed
acts_upstream_of_or_within_positive_effect flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol metabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

NP_498783.1

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