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magu-3 Guanylate kinase-like domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 183676, updated on 2-Nov-2024

Summary

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Official Symbol
magu-3
Official Full Name
Guanylate kinase-like domain-containing protein
Primary source
WormBase:WBGene00016841
Locus tag
CELE_C50F2.8
See related
AllianceGenome:WB:WBGene00016841
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable kinase activity. Predicted to be active in cell-cell junction and plasma membrane. Is expressed in intestine; pharynx; and tail. Orthologous to human PALS2 (protein associated with LIN7 2, MAGUK p55 family member). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See magu-3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
8
Sequence:
Chromosome: I; NC_003279.8 (3901421..3905208, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Tyrosine-protein phosphatase domain-containing protein Neighboring gene peptidylprolyl isomerase Neighboring gene Sialomucin core protein 24 Neighboring gene ncRNA Neighboring gene Proteasome subunit beta type-2 Neighboring gene Ribosome-recycling factor, mitochondrial Neighboring gene TPA-induced transmembrane protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
  2. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
  3. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
  4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Guanylate kinase-like domain-containing protein
NP_491260.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    3901421..3905208 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058859.5 → NP_491260.2  Guanylate kinase-like domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491260.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    P91182
    Conserved Domains (3) summary
    pfam00625
    Location:282 → 464
    Guanylate_kin; Guanylate kinase
    cl00117
    Location:147 → 204
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cl17036
    Location:218 → 268
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein
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