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clec-86 C-type lectin domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 183775, updated on 2-Nov-2024

Summary

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Official Symbol
clec-86
Official Full Name
C-type lectin domain-containing protein
Primary source
WormBase:WBGene00016912
Locus tag
CELE_C54D1.2
See related
AllianceGenome:WB:WBGene00016912
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable carbohydrate binding activity and pattern recognition receptor activity. Involved in innate immune response. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human REG1A (regenerating family member 1 alpha); REG1B (regenerating family member 1 beta); and REG3G (regenerating family member 3 gamma). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See clec-86 in Genome Data Viewer
Location:
chromosome: X
Exon count:
3
Sequence:
Chromosome: X; NC_003284.9 (7139875..7140566)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene HEsitatioN behavior Neighboring gene IRS-type PTB domain-containing protein Neighboring gene ncRNA Neighboring gene Aldehyde dehydrogenase domain-containing protein Neighboring gene Laminin-like protein lam-2 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genomic clusters, putative pathogen recognition molecules, and antimicrobial genes are induced by infection of C. elegans with M. nematophilum. O'Rourke D, et al. Genome Res, 2006 Aug. PMID 16809667, Free PMC Article
  2. Salmonella enterica serovar Paratyphi A-induced immune response in Caenorhabditis elegans depends on MAPK pathways and DAF-16. Ding AJ, et al. Front Immunol, 2023. PMID 37122724, Free PMC Article
  3. Specificity of the innate immune system and diversity of C-type lectin domain (CTLD) proteins in the nematode Caenorhabditis elegans. Schulenburg H, et al. Immunobiology, 2008. PMID 18406370
  4. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Shapira M, et al. Proc Natl Acad Sci U S A, 2006 Sep 19. PMID 16968778, Free PMC Article
  5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables carbohydrate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pattern recognition receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response HEP PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
C-type lectin domain-containing protein
NP_509202.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    7139875..7140566
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076801.2 → NP_509202.1  C-type lectin domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509202.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18821
    Conserved Domains (1) summary
    smart00034
    Location:20 → 144
    CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
Nucleotide Protein
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