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mdt-18 Mediator of RNA polymerase II transcription subunit 18 [ Caenorhabditis elegans ]

Gene ID: 183844, updated on 2-Nov-2024

Summary

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Official Symbol
mdt-18
Official Full Name
Mediator of RNA polymerase II transcription subunit 18
Primary source
WormBase:WBGene00007018
Locus tag
CELE_C55B7.9
See related
AllianceGenome:WB:WBGene00007018
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable transcription coregulator activity. Predicted to be involved in positive regulation of transcription initiation by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Orthologous to human MED18 (mediator complex subunit 18). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mdt-18 in Genome Data Viewer
Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003279.8 (6492720..6495253, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Chromo domain-containing protein Neighboring gene CTLH domain-containing protein;WD_REPEATS_REGION domain-containing protein Neighboring gene STAS domain-containing protein Neighboring gene ncRNA Neighboring gene Lariat debranching enzyme Neighboring gene Unconventional prefoldin RPB5 interactor Neighboring gene Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial Neighboring gene Protein-tyrosine phosphatase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Domain selection combined with improved cloning strategy for high throughput expression of higher eukaryotic proteins. Chen Y, et al. BMC Biotechnol, 2007 Jul 30. PMID 17663785, Free PMC Article
  2. Alignment of the genetic and physical maps in the dpy-5 bli-4 (I) region of C. elegans by the serial cosmid rescue of lethal mutations. McDowall JS, et al. Mol Gen Genet, 1997 Jun. PMID 9230901
  3. Transcriptional control of cell-cycle quiescence during C. elegans development. Clayton JE, et al. Dev Biol, 2008 Jan 15. PMID 18082681, Free PMC Article
  4. Genetic analysis of sterile mutants in the dpy-5 unc-13 (I) genomic region of Caenorhabditis elegans. McDowall JS, et al. Mol Gen Genet, 1997 Jun. PMID 9230900
  5. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Yang F, et al. Nature, 2006 Aug 10. PMID 16799563

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription initiation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of core mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mediator of RNA polymerase II transcription subunit 18
NP_001380190.1
  • Confirmed by transcript evidence
NP_491869.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    6492720..6495253 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392449.1 → NP_001380190.1  Mediator of RNA polymerase II transcription subunit 18 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MCJ5
    Conserved Domains (1) summary
    pfam09637
    Location:5 → 157
    Med18; Med18 protein

  2. NM_059468.7 → NP_491869.1  Mediator of RNA polymerase II transcription subunit 18 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491869.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q966M5
    Conserved Domains (1) summary
    pfam09637
    Location:26 → 218
    Med18; Med18 protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q966M5.1

Gene LinkOut

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