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nhr-137 NR LBD domain-containing protein;Nuclear receptor [ Caenorhabditis elegans ]

Gene ID: 183865, updated on 2-Nov-2024

Summary

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Official Symbol
nhr-137
Official Full Name
NR LBD domain-containing protein;Nuclear receptor
Primary source
WormBase:WBGene00003727
Locus tag
CELE_C56E10.4
See related
AllianceGenome:WB:WBGene00003727
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be located in membrane and nucleus. Is expressed in intestine and neurons. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nhr-137 in Genome Data Viewer
Location:
chromosome: X
Exon count:
13
Sequence:
Chromosome: X; NC_003284.9 (6661772..6669011, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Coiled-coil domain-containing protein 96 Neighboring gene Nuclear receptor Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Collagen triple helix repeat protein;Nematode cuticle collagen N-terminal domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
  2. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
  3. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article
  4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NR LBD domain-containing protein;Nuclear receptor
NP_001024505.1
  • Confirmed by transcript evidence
NP_001024506.1
  • Confirmed by transcript evidence
NP_001041235.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    6661772..6669011 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029334.4 → NP_001024505.1  NR LBD domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024505.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EEX1
    Conserved Domains (2) summary
    smart00430
    Location:168 → 329
    HOLI; Ligand binding domain of hormone receptors
    cl02596
    Location:52 → 73
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

  2. NM_001029335.7 → NP_001024506.1  Nuclear receptor [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024506.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B3WFU1
    Conserved Domains (2) summary
    cd06916
    Location:67 → 142
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    smart00430
    Location:237 → 398
    HOLI; Ligand binding domain of hormone receptors

  3. NM_001047770.5 → NP_001041235.1  NR LBD domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041235.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B3WFU2
    Conserved Domains (1) summary
    smart00430
    Location:101 → 262
    HOLI; Ligand binding domain of hormone receptors
Nucleotide Protein
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