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smp-2 Sema domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 183905, updated on 2-Nov-2024

Summary

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Official Symbol
smp-2
Official Full Name
Sema domain-containing protein
Primary source
WormBase:WBGene00004890
Locus tag
CELE_D1037.2
See related
AllianceGenome:WB:WBGene00004890
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable chemorepellent activity and semaphorin receptor binding activity. Involved in nematode male tail mating organ morphogenesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including inner labial neurons; intestinal cell; pharyngeal cell; ray; and sex organ. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy. Orthologous to several human genes including SEMA6A (semaphorin 6A); SEMA6B (semaphorin 6B); and SEMA6C (semaphorin 6C). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See smp-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
11
Sequence:
Chromosome: I; NC_003279.8 (3666490..3671700, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene DEgenerin Like Neighboring gene Ferritin Neighboring gene Ras-related protein Rab-8A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Semaphorin 1a and semaphorin 1b are required for correct epidermal cell positioning and adhesion during morphogenesis in C. elegans. Ginzburg VE, et al. Development, 2002 May. PMID 11959817
  2. Semaphorin signaling restricts neuronal regeneration in C. elegans. Harreguy MB, et al. Front Cell Dev Biol, 2022. PMID 36325362, Free PMC Article
  3. mab-20 encodes Semaphorin-2a and is required to prevent ectopic cell contacts during epidermal morphogenesis in Caenorhabditis elegans. Roy PJ, et al. Development, 2000 Feb. PMID 10648234
  4. Caenorhabditis elegans PlexinA, PLX-1, interacts with transmembrane semaphorins and regulates epidermal morphogenesis. Fujii T, et al. Development, 2002 May. PMID 11959816
  5. Vulva morphogenesis involves attraction of plexin 1-expressing primordial vulva cells to semaphorin 1a sequentially expressed at the vulva midline. Dalpé G, et al. Development, 2005 Mar. PMID 15716342

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables chemorepellent activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables semaphorin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables semaphorin receptor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nematode male tail mating organ morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nematode male tail mating organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in semaphorin-plexin signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Sema domain-containing protein
NP_491197.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    3666490..3671700 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058796.6 → NP_491197.3  Sema domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491197.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9TYS4
    Conserved Domains (2) summary
    smart00630
    Location:47 → 429
    Sema; semaphorin domain
    cl15693
    Location:390 → 478
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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