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maco-1 Macoilin [ Caenorhabditis elegans ]

Gene ID: 183963, updated on 2-Nov-2024

Summary

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Official Symbol
maco-1
Official Full Name
Macoilin
Primary source
WormBase:WBGene00017066
Locus tag
CELE_D2092.5
See related
AllianceGenome:WB:WBGene00017066
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable microtubule binding activity. Involved in chemotaxis; neuronal signal transduction; and thermotaxis. Located in neuronal cell body; nuclear envelope; and rough endoplasmic reticulum. Is expressed in epithelial cell; muscle cell; and nervous system. Orthologous to human MACO1 (macoilin 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See maco-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
13
Sequence:
Chromosome: I; NC_003279.8 (6598982..6607520, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene SH2 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Thioredoxin domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. C. elegans interprets bacterial non-coding RNAs to learn pathogenic avoidance. Kaletsky R, et al. Nature, 2020 Oct. PMID 32908307, Free PMC Article
  2. Novel and conserved protein macoilin is required for diverse neuronal functions in Caenorhabditis elegans. Miyara A, et al. PLoS Genet, 2011 May. PMID 21589894, Free PMC Article
  3. Macoilin, a conserved nervous system-specific ER membrane protein that regulates neuronal excitability. Arellano-Carbajal F, et al. PLoS Genet, 2011 Mar. PMID 21437263, Free PMC Article
  4. Multiple Signaling Pathways Coordinately Regulate Forgetting of Olfactory Adaptation through Control of Sensory Responses in Caenorhabditis elegans. Kitazono T, et al. J Neurosci, 2017 Oct 18. PMID 28924007, Free PMC Article
  5. A Forward Genetic Screen for Molecules Involved in Pheromone-Induced Dauer Formation in Caenorhabditis elegans. Neal SJ, et al. G3 (Bethesda), 2016 May 3. PMID 26976437, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results suggest that macoilin is required for various neural events, such as the regulation of neuronal activity
    Title: Novel and conserved protein macoilin is required for diverse neuronal functions in Caenorhabditis elegans.
  2. macoilin acts in the endoplasmic reticulum to regulate assembly or traffic of ion channels or ion channel regulators
    Title: Macoilin, a conserved nervous system-specific ER membrane protein that regulates neuronal excitability.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuronal signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuronal signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in neuronal signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in thermotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in rough endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in rough endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in rough endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Macoilin
NP_491902.4
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    6598982..6607520 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059501.7 → NP_491902.4  Macoilin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491902.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P91193
    Conserved Domains (1) summary
    pfam09726
    Location:38 → 707
    Macoilin; Transmembrane protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P91193.4

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