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pgp-11 P-GlycoProtein related [ Caenorhabditis elegans ]

Gene ID: 183971, updated on 2-Nov-2024

Summary

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Official Symbol
pgp-11
Official Full Name
P-GlycoProtein related
Primary source
WormBase:WBGene00004005
Locus tag
CELE_DH11.3
See related
AllianceGenome:WB:WBGene00004005
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to be active in membrane. Is expressed in excretory cell; intestine; and rectal gland cell. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pgp-11 in Genome Data Viewer
Location:
chromosome: II
Exon count:
17
Sequence:
Chromosome: II; NC_003280.10 (7995580..8004257, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene C2 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Putative glutaminase 2;glutaminase Neighboring gene F-box domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transgenically expressed Parascaris P-glycoprotein-11 can modulate ivermectin susceptibility in Caenorhabditis elegans. Janssen IJ, et al. Int J Parasitol Drugs Drug Resist, 2015 Aug. PMID 25905032, Free PMC Article
  2. Distinct regulatory elements mediate similar expression patterns in the excretory cell of Caenorhabditis elegans. Zhao Z, et al. J Biol Chem, 2005 Nov 18. PMID 16159881
  3. Resistance to the macrocyclic lactone moxidectin is mediated in part by membrane transporter P-glycoproteins: Implications for control of drug resistant parasitic nematodes. Bygarski EE, et al. Int J Parasitol Drugs Drug Resist, 2014 Dec. PMID 25516824, Free PMC Article
  4. The ABC transporter gene family of Caenorhabditis elegans has implications for the evolutionary dynamics of multidrug resistance in eukaryotes. Sheps JA, et al. Genome Biol, 2004. PMID 15003118, Free PMC Article
  5. Comparative genomics and adaptive selection of the ATP-binding-cassette gene family in caenorhabditis species. Zhao Z, et al. Genetics, 2007 Mar. PMID 17194779, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to chemical IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
P-GlycoProtein related
NP_001364583.1
  • Product from WormBase gene class pgp;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    7995580..8004257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001377827.2 → NP_001364583.1  P-GlycoProtein related [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19015
    Conserved Domains (2) summary
    COG1132
    Location:46 → 607
    MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
    PTZ00265
    Location:38 → 1235
    PTZ00265; multidrug resistance protein (mdr1); Provisional
Nucleotide Protein
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