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nhr-121 Nuclear hormone receptor family member nhr-121 [ Caenorhabditis elegans ]

Gene ID: 184003, updated on 2-Nov-2024

Summary

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Official Symbol
nhr-121
Official Full Name
Nuclear hormone receptor family member nhr-121
Primary source
WormBase:WBGene00003711
Locus tag
CELE_E02H9.8
See related
AllianceGenome:WB:WBGene00003711
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables steroid hormone binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nhr-121 in Genome Data Viewer
Location:
chromosome: III
Exon count:
11
Sequence:
Chromosome: III; NC_003281.10 (2449338..2454807, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene Glycoside hydrolase family 1 protein Neighboring gene pseudo Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of an estrogenic hormone receptor in Caenorhabditis elegans. Mimoto A, et al. Biochem Biophys Res Commun, 2007 Dec 28. PMID 17963693
  2. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
  3. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
  4. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
  5. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables steroid hormone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nuclear hormone receptor family member nhr-121
NP_001122691.1
  • Confirmed by transcript evidence
NP_497559.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    2449338..2454807 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001129219.6 → NP_001122691.1  Nuclear hormone receptor family member nhr-121 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122691.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8WJ04
    Conserved Domains (2) summary
    cd06157
    Location:241 → 427
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    cd06960
    Location:22 → 97
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

  2. NM_065158.7 → NP_497559.2  Nuclear hormone receptor family member nhr-121 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497559.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9TZ99
    Conserved Domains (2) summary
    cd06157
    Location:241 → 425
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    cd06960
    Location:22 → 97
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9TZ99.2

Gene LinkOut

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