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ccpp-6 Cytosolic carboxypeptidase 6 [ Caenorhabditis elegans ]

Gene ID: 184043, updated on 2-Nov-2024

Summary

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Official Symbol
ccpp-6
Official Full Name
Cytosolic carboxypeptidase 6
Primary source
WormBase:WBGene00017136
Locus tag
CELE_EEED8.6
See related
AllianceGenome:WB:WBGene00017136
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables metallocarboxypeptidase activity. Involved in egg-laying behavior; protein deglutamylation; and proteolysis. Predicted to be active in ciliary basal body and cytoplasm. Is expressed in nervous system. Orthologous to human AGBL4 (AGBL carboxypeptidase 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ccpp-6 in Genome Data Viewer
Location:
chromosome: II
Exon count:
10
Sequence:
Chromosome: II; NC_003280.10 (5384137..5387317, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Peroxiredoxin prdx-2 Neighboring gene ncRNA Neighboring gene Protein kinase C-like 3 Neighboring gene putative splicing factor, arginine/serine-rich 4 Neighboring gene Putative nudix hydrolase 6 Neighboring gene BRCA1-associated protein homolog 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The C. elegans deglutamylase CCPP-6 does not operate redundantly with CCPP-1 in gross cilia integrity. Klimas AS, et al. MicroPubl Biol, 2023. PMID 37287505, Free PMC Article
  2. A ccpp-6 deletion mutation does not impair gross cilia integrity in C. elegans. Dominguez J, et al. MicroPubl Biol, 2022. PMID 36285326, Free PMC Article
  3. Kinesin-13 and tubulin posttranslational modifications regulate microtubule growth in axon regeneration. Ghosh-Roy A, et al. Dev Cell, 2012 Oct 16. PMID 23000142, Free PMC Article
  4. Nna1-like proteins are active metallocarboxypeptidases of a new and diverse M14 subfamily. Rodriguez de la Vega M, et al. FASEB J, 2007 Mar. PMID 17244817
  5. Regenerating motor neurons express Nna1, a novel ATP/GTP-binding protein related to zinc carboxypeptidases. Harris A, et al. Mol Cell Neurosci, 2000 Nov. PMID 11083920

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. two evolutionarily divergent systems identify C. elegans CCPP-6 and its mammalian ortholog CCP5 as a tubulin deglutamylase
    Title: Identification of tubulin deglutamylase among Caenorhabditis elegans and mammalian cytosolic carboxypeptidases (CCPs).
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallocarboxypeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metallocarboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallocarboxypeptidase activity TAS
Traceable Author Statement
more info
 PubMed 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein deglutamylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Cytosolic carboxypeptidase 6
NP_495012.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    5384137..5387317 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_062611.6 → NP_495012.2  Cytosolic carboxypeptidase 6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495012.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09296
    Conserved Domains (1) summary
    cd06908
    Location:153 → 418
    M14_AGBL4_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-4 and related proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09296.2

Gene LinkOut

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