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Orm2 orosomucoid 2 [ Mus musculus (house mouse) ]

Gene ID: 18406, updated on 11-Nov-2024

Summary

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Official Symbol
Orm2provided by MGI
Official Full Name
orosomucoid 2provided by MGI
Primary source
MGI:MGI:97444
See related
Ensembl:ENSMUSG00000061540 AllianceGenome:MGI:97444
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Agp1; Orm-2
Summary
Predicted to enable small molecule binding activity. Predicted to be involved in acute-phase response and regulation of immune system process. Predicted to be active in extracellular space. Orthologous to several human genes including ORM2 (orosomucoid 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver adult (RPKM 37.5), subcutaneous fat pad adult (RPKM 8.0) and 2 other tissues See more
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Genomic context

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See Orm2 in Genome Data Viewer
Location:
4 B3; 4 33.96 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (63280543..63284114)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (63362449..63365877)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene orosomucoid 1 pseudogene Neighboring gene orosomucoid 3 Neighboring gene AT-hook transcription factor Neighboring gene AT-hook transcription factor, opposite strand Neighboring gene predicted gene, 52742

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1/2-PPARγ-Cd36 pathway. Li L, et al. Cell Rep, 2023 Jul 25. PMID 37355990
  2. Orm2 Deficiency Aggravates High-Fat Diet-Induced Obesity through Gut Microbial Dysbiosis and Intestinal Inflammation. Li L, et al. Mol Nutr Food Res, 2024 Jan. PMID 37853937
  3. An acute phase protein α(1)-acid glycoprotein mitigates AKI and its progression to CKD through its anti-inflammatory action. Watanabe H, et al. Sci Rep, 2021 Apr 12. PMID 33846468, Free PMC Article
  4. A synthetic retinoic acid receptor agonist Am80 ameliorates renal fibrosis via inducing the production of alpha-1-acid glycoprotein. Watanabe H, et al. Sci Rep, 2020 Jul 10. PMID 32651445, Free PMC Article
  5. Nucleotide sequence of the mouse alpha 1-acid glycoprotein gene 1. Cooper R, et al. Biochemistry, 1987 Aug 25. PMID 3676251

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Orm2 Deficiency Aggravates High-Fat Diet-Induced Obesity through Gut Microbial Dysbiosis and Intestinal Inflammation.
    Title: Orm2 Deficiency Aggravates High-Fat Diet-Induced Obesity through Gut Microbial Dysbiosis and Intestinal Inflammation.
  2. Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1/2-PPARgamma-Cd36 pathway.
    Title: Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1/2-PPARγ-Cd36 pathway.
  3. Orosomucoid 2 maintains hepatic lipid homeostasis through suppression of de novo lipogenesis.
    Title: Orosomucoid 2 maintains hepatic lipid homeostasis through suppression of de novo lipogenesis.
  4. The bile acid induced hepatokine orosomucoid suppresses adipocyte differentiation.
    Title: The bile acid induced hepatokine orosomucoid suppresses adipocyte differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4)  1 citation
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables small molecule binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in acute-phase response IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of immune system process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
alpha-1-acid glycoprotein 2
Names
AGP 2
OMD 2
bM340H1.5 (orosomucoid 2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011016.2 → NP_035146.1  alpha-1-acid glycoprotein 2 precursor

    See identical proteins and their annotated locations for NP_035146.1

    Status: VALIDATED

    Source sequence(s)
    CB949119, M27009
    Consensus CDS
    CCDS18253.1
    UniProtKB/Swiss-Prot
    P07361
    Related
    ENSMUSP00000074810.4, ENSMUST00000075341.4
    Conserved Domains (1) summary
    pfam00061
    Location:43 → 181
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    63280543..63284114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163821.1 → XP_036019714.1  alpha-1-acid glycoprotein 2 isoform X1

    Conserved Domains (1) summary
    cl10502
    Location:21 → 145
    lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07361.1 GenPept UniProtKB/Swiss-Prot:P07361

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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