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Orm3 orosomucoid 3 [ Mus musculus (house mouse) ]

Gene ID: 18407, updated on 2-Nov-2024

Summary

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Official Symbol
Orm3provided by MGI
Official Full Name
orosomucoid 3provided by MGI
Primary source
MGI:MGI:97445
See related
Ensembl:ENSMUSG00000028359 AllianceGenome:MGI:97445
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Agp-3; Orm-3
Summary
Predicted to enable small molecule binding activity. Predicted to be involved in acute-phase response and regulation of immune system process. Predicted to be active in extracellular space. Orthologous to several human genes including ORM2 (orosomucoid 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver adult (RPKM 2.8), subcutaneous fat pad adult (RPKM 2.0) and 7 other tissues See more
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Genomic context

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See Orm3 in Genome Data Viewer
Location:
4 B3; 4 33.96 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (63274107..63277748)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (63356069..63359506)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene orosomucoid 1 Neighboring gene orosomucoid 1 pseudogene Neighboring gene orosomucoid 2 Neighboring gene AT-hook transcription factor Neighboring gene AT-hook transcription factor, opposite strand

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Differential expression of the mouse alpha 1-acid glycoprotein genes (AGP-1 and AGP-2) during inflammation and aging. Carter KC, et al. Biochim Biophys Acta, 1991 Jun 13. PMID 2054382
  2. The bile acid induced hepatokine orosomucoid suppresses adipocyte differentiation. Lee SH, et al. Biochem Biophys Res Commun, 2021 Jan 1. PMID 33168190, Free PMC Article
  3. A mouse gene family associated with a major submaxillary-gland glycoprotein. Craig AG, et al. Biochem J, 1985 Feb 1. PMID 3977853, Free PMC Article
  4. Evidence for the existence of multiple alpha 1-acid glycoprotein genes in the mouse. Cooper R, et al. J Biol Chem, 1986 Feb 5. PMID 3003086
  5. Structure and expression of mouse alpha 1-acid glycoprotein gene-3 (AGP-3). Chang CJ, et al. DNA Cell Biol, 1992 May. PMID 1605854

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The bile acid induced hepatokine orosomucoid suppresses adipocyte differentiation.
    Title: The bile acid induced hepatokine orosomucoid suppresses adipocyte differentiation.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables small molecule binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in acute-phase response IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of immune system process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
alpha-1-acid glycoprotein 3
Names
AGP 3
OMD 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379520.1 → NP_001366449.1  alpha-1-acid glycoprotein 3 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL683828
    UniProtKB/TrEMBL
    B7ZP06, B9EIY6
    Conserved Domains (1) summary
    cd19451
    Location:21 → 195
    lipocalin_AGP-like; alpha1-acid glycoprotein and similar proteins

  2. NM_001379521.1 → NP_001366450.1  alpha-1-acid glycoprotein 3 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL683828

  3. NM_013623.3 → NP_038651.2  alpha-1-acid glycoprotein 3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_038651.2

    Status: VALIDATED

    Source sequence(s)
    AL683828
    Consensus CDS
    CCDS18252.1
    UniProtKB/TrEMBL
    B7ZP06, J3JRU4
    Related
    ENSMUSP00000006687.5, ENSMUST00000006687.5
    Conserved Domains (1) summary
    pfam00061
    Location:40 → 180
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RNA

  1. NR_166739.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL683828

  2. NR_166740.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL683828

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    63274107..63277748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537666.5 → XP_006537729.1  alpha-1-acid glycoprotein 3 isoform X1

    Conserved Domains (1) summary
    cl10502
    Location:21 → 182
    lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

  2. XM_006537669.5 → XP_006537732.1  alpha-1-acid glycoprotein 3 isoform X3

    Conserved Domains (1) summary
    cl10502
    Location:21 → 146
    lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

  3. XM_036163822.1 → XP_036019715.1  alpha-1-acid glycoprotein 3 isoform X4

    UniProtKB/Swiss-Prot
    Q63805
    Conserved Domains (1) summary
    cl10502
    Location:21 → 159
    lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

  4. XM_006537667.4 → XP_006537730.1  alpha-1-acid glycoprotein 3 isoform X2

    Conserved Domains (1) summary
    cl10502
    Location:18 → 162
    lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63805.1 GenPept UniProtKB/Swiss-Prot:Q63805

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