Cldn11 claudin 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cldn11provided by MGI
Official Full Name: claudin 11provided by MGI
Primary source: MGI:MGI:106925
See related: Ensembl:ENSMUSG00000037625 AllianceGenome:MGI:106925
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Osp; Otm; Claudin11; Claudin-11
Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of CNS (central nervous system) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. The basal cell tight junctions in stria vascularis are primarily composed of this protein, and the gene-null mice suffer severe deafness. This protein is also an obligatory protein for tight junction formation and barrier integrity in the testis and the gene deficiency results in loss of the Sertoli cell epithelial phenotype in the testis. [provided by RefSeq, Aug 2010]
Expression: Biased expression in cerebellum adult (RPKM 80.9), cortex adult (RPKM 73.0) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 A3; 3 15.14 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (31204069..31218475)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (31149920..31164326)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CCL21 and CLDN11 Are Key Driving Factors of Lymph Node Metastasis in Gastric Cancer.
Title: CCL21 and CLDN11 Are Key Driving Factors of Lymph Node Metastasis in Gastric Cancer.
Chronic unpredictable stress disturbs the blood-testis barrier affecting sperm parameters in mice.
Title: Chronic unpredictable stress disturbs the blood-testis barrier affecting sperm parameters in mice.
Novel Role for Claudin-11 in the Regulation of Osteoblasts via Modulation of ADAM10-Mediated Notch Signaling.
Title: Novel Role for Claudin-11 in the Regulation of Osteoblasts via Modulation of ADAM10-Mediated Notch Signaling.
The enhancement of osteoblast differentiation by positive feedback of Cldn11 was achieved through the phosphorylation of Smad1/5/8, ERK, and c-Jun amino-terminal kinase.
Title: Claudin 11 regulates bone homeostasis via bidirectional EphB4-EphrinB2 signaling.
Absence of Claudin 11 in CNS Myelin Perturbs Behavior and Neurotransmitter Levels in Mice
Title: Absence of Claudin 11 in CNS Myelin Perturbs Behavior and Neurotransmitter Levels in Mice.
expressions of Claudin-11 were observed between Sertoli cells and disrupted in the testes of syndrome group mice.
Title: Contemporaneous effects of diabetes mellitus and hypothyroidism on spermatogenesis and immunolocalization of Claudin-11 inside the seminiferous tubules of mice.
Absence of claudin 11 in CNS myelin causes behavioral phenotypes and neurotransmitter imbalances in amygdala and auditory brainstem
Title: Absence of Claudin 11 in CNS Myelin Perturbs Behavior and Neurotransmitter Levels in Mice.
Results show that the primary function of claudin-11 is to provide a barrier that impedes the diffusion of material through the intramyelinic compartment
Title: Claudin-11 Tight Junctions in Myelin Are a Barrier to Diffusion and Lack Strong Adhesive Properties.
The present study provides the first evidence that DPT may be a novel effector of cadmium chloride, highlighting the significant role of DPT in the regulation of claudin-11 expression
Title: Dermatopontin is a novel regulator of the CdCl2-induced decrease in claudin-11 expression.
Local radiation-induced testicular oxidative stress can elevate the expression of claudin-11 in the testis tissue.
Title: [Radiation-induced oxidative stress and claudin-11 mRNA expression in the testis].

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU048398 (e-PCR)
- UniSTS:109574

U19582 (e-PCR)
- UniSTS:159102

Cldn11 (e-PCR), detects polymorphism
- UniSTS:256662

Cldn11 (e-PCR), detects polymorphism
- UniSTS:465375

Cldn11 (e-PCR), detects polymorphism
- UniSTS:495869

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon ensheathment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bicellular tight junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tight junction assembly	IEA Inferred from Electronic Annotation more info
involved_in tight junction assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in basal part of cell	IDA Inferred from Direct Assay more info	PubMed
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in bicellular tight junction	ISS Inferred from Sequence or Structural Similarity more info
located_in bicellular tight junction	TAS Traceable Author Statement more info	PubMed
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in myelin sheath	HDA more info	PubMed
located_in neurofilament	IEA Inferred from Electronic Annotation more info
located_in neurofilament	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in tight junction	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: claudin-11

Names: oligodendrocyte transmembrane protein; oligodendrocyte-specific protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.