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ced-8 Cell death abnormality protein 8 [ Caenorhabditis elegans ]

Gene ID: 184190, updated on 2-Nov-2024

Summary

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Official Symbol
ced-8
Official Full Name
Cell death abnormality protein 8
Primary source
WormBase:WBGene00000422
Locus tag
CELE_F08F1.5
See related
AllianceGenome:WB:WBGene00000422
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables phospholipid scramblase activity. Involved in several processes, including apoptotic process involved in development; engulfment of apoptotic cell; and phosphatidylserine exposure on apoptotic cell surface. Located in plasma membrane. Orthologous to several human genes including XKR6 (XK related 6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ced-8 in Genome Data Viewer
Location:
chromosome: X
Exon count:
9
Sequence:
Chromosome: X; NC_003284.9 (8414006..8416919, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Cyclin-like domain-containing protein Neighboring gene ncRNA Neighboring gene C6 domain-containing protein Neighboring gene Saposin B-type domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Leu Neighboring gene Transmembrane 9 superfamily member Neighboring gene ncRNA Neighboring gene tRNA-Leu

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mechanisms of apoptotic phosphatidylserine exposure. Mariño G, et al. Cell Res, 2013 Nov. PMID 23979019, Free PMC Article
  2. The ced-8 gene controls the timing of programmed cell deaths in C. elegans. Stanfield GM, et al. Mol Cell, 2000 Mar. PMID 10882128
  3. Necrotic Cells Actively Attract Phagocytes through the Collaborative Action of Two Distinct PS-Exposure Mechanisms. Li Z, et al. PLoS Genet, 2015 Jun. PMID 26061275, Free PMC Article
  4. Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells. Suzuki J, et al. Science, 2013 Jul 26. PMID 23845944
  5. The nongenotoxic carcinogens naphthalene and para-dichlorobenzene suppress apoptosis in Caenorhabditis elegans. Kokel D, et al. Nat Chem Biol, 2006 Jun. PMID 16699520

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables phospholipid scramblase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic process involved in development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in apoptotic process involved in development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in apoptotic process involved in development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in engulfment of apoptotic cell IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in engulfment of apoptotic cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in execution phase of apoptosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylserine exposure on apoptotic cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylserine exposure on apoptotic cell surface IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cell death abnormality protein 8
NP_509427.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    8414006..8416919 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077026.10 → NP_509427.2  Cell death abnormality protein 8 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509427.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O17386
    Conserved Domains (1) summary
    pfam09815
    Location:45 → 402
    XK-related; XK-related protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O17386.2

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