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irg-4 CUB-like domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 184206, updated on 2-Nov-2024

Summary

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Official Symbol
irg-4
Official Full Name
CUB-like domain-containing protein
Primary source
WormBase:WBGene00008584
Locus tag
CELE_F08G5.6
See related
AllianceGenome:WB:WBGene00008584
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in defense response to Gram-negative bacterium and innate immune response. Is expressed in head neurons and intestine. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See irg-4 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
7
Sequence:
Chromosome: IV; NC_003282.8 (12435833..12438236)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase subunit 1;UDP-glucuronosyltransferase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene C-type lectin domain-containing protein Neighboring gene C-type lectin domain-containing protein Neighboring gene C-type lectin domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Association with soil bacteria enhances p38-dependent infection resistance in Caenorhabditis elegans. Montalvo-Katz S, et al. Infect Immun, 2013 Feb. PMID 23230286, Free PMC Article
  2. A MAP Kinase pathway in Caenorhabditis elegans is required for defense against infection by opportunistic Proteus species. JebaMercy G, et al. Microbes Infect, 2013 Jul-Aug. PMID 23597661
  3. Effects of sequential infections of Caenorhabditis elegans with Staphylococcus aureus and Proteus mirabilis. JebaMercy G, et al. Microbiol Immunol, 2012 Dec. PMID 22957781
  4. Stimulation of host immune defenses by a small molecule protects C. elegans from bacterial infection. Pukkila-Worley R, et al. PLoS Genet, 2012. PMID 22719261, Free PMC Article
  5. Physiological and Immunological Regulations in Caenorhabditis elegans Infected with Salmonella enterica serovar Typhi. Sivamaruthi BS, et al. Indian J Microbiol, 2014 Mar. PMID 24426167, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response HEP PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
CUB-like domain-containing protein
NP_502374.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    12435833..12438236
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069973.7 → NP_502374.1  CUB-like domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502374.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19223
    Conserved Domains (1) summary
    pfam02408
    Location:14 → 133
    CUB_2; CUB-like domain
Nucleotide Protein
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