dmd-5 Doublesex- and mab-3-related transcription factor dmd-5 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: dmd-5
Official Full Name: Doublesex- and mab-3-related transcription factor dmd-5
Primary source: WormBase:WBGene00017326
Locus tag: CELE_F10C1.5
See related: AllianceGenome:WB:WBGene00017326
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in male anatomical structure morphogenesis and negative regulation of synapse pruning. Predicted to be active in nucleus. Is expressed in intestine; nervous system; and in male. Orthologous to human DMRTA2 (DMRT like family A2) and DMRTB1 (DMRT like family B with proline rich C-terminal 1). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in male anatomical structure morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of synapse pruning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in sex differentiation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_495138.2

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