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eak-6 Tyrosine-protein phosphatase non-receptor type eak-6 [ Caenorhabditis elegans ]

Gene ID: 184324, updated on 2-Nov-2024

Summary

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Official Symbol
eak-6
Official Full Name
Tyrosine-protein phosphatase non-receptor type eak-6
Primary source
WormBase:WBGene00008663
Locus tag
CELE_F10G8.4
See related
AllianceGenome:WB:WBGene00008663
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein tyrosine phosphatase activity. Involved in dauer larval development. Located in plasma membrane. Is expressed in XXXL and XXXR. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See eak-6 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (10023798..10025838)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Protein-tyrosine phosphatase Neighboring gene Protein kinase domain-containing protein Neighboring gene mRNA export factor rae-1 Neighboring gene ERCC1-like central domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling. Hu PJ, et al. PLoS Genet, 2006 Jul. PMID 16839187, Free PMC Article
  2. Functional divergence of dafachronic acid pathways in the control of C. elegans development and lifespan. Dumas KJ, et al. Dev Biol, 2010 Apr 15. PMID 20178781, Free PMC Article
  3. Caenorhabditis elegans EAK-3 inhibits dauer arrest via nonautonomous regulation of nuclear DAF-16/FoxO activity. Zhang Y, et al. Dev Biol, 2008 Mar 15. PMID 18241854, Free PMC Article
  4. EAK-7 controls development and life span by regulating nuclear DAF-16/FoxO activity. Alam H, et al. Cell Metab, 2010 Jul 7. PMID 20620993, Free PMC Article
  5. Axon guidance genes identified in a large-scale RNAi screen using the RNAi-hypersensitive Caenorhabditis elegans strain nre-1(hd20) lin-15b(hd126). Schmitz C, et al. Proc Natl Acad Sci U S A, 2007 Jan 16. PMID 17213328, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
NOT enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in dauer larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in dauer larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Tyrosine-protein phosphatase non-receptor type eak-6
NP_001122448.1
  • Confirmed by transcript evidence
NP_001122449.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    10023798..10025838
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001128976.3 → NP_001122448.1  Tyrosine-protein phosphatase non-receptor type eak-6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122448.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EGU2
    Conserved Domains (2) summary
    smart00194
    Location:36 → 308
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:66 → 307
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  2. NM_001128977.1 → NP_001122449.1  Tyrosine-protein phosphatase non-receptor type eak-6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122449.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EEU5, G5EGU2
    Conserved Domains (2) summary
    smart00194
    Location:36 → 308
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:66 → 307
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EGU2.1

Gene LinkOut

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