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sid-5 Systemic RNA interference defective protein 5 [ Caenorhabditis elegans ]

Gene ID: 184450, updated on 2-Nov-2024

Summary

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Official Symbol
sid-5
Official Full Name
Systemic RNA interference defective protein 5
Primary source
WormBase:WBGene00017445
Locus tag
CELE_F14B8.2
See related
AllianceGenome:WB:WBGene00017445
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in RNA transport and regulatory ncRNA-mediated post-transcriptional gene silencing. Located in late endosome. Is expressed in several structures, including gonad; intestine; muscle cell; neurons; and somatic cell. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sid-5 in Genome Data Viewer
Location:
chromosome: X
Exon count:
3
Sequence:
Chromosome: X; NC_003284.9 (6904721..6905849)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene ncRNA Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene tRNA-Leu Neighboring gene ncRNA Neighboring gene Sodium/hydrogen exchanger Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The conserved SNARE SEC-22 localizes to late endosomes and negatively regulates RNA interference in Caenorhabditis elegans. Zhao Y, et al. RNA, 2017 Mar. PMID 27974622, Free PMC Article
  2. RNA interference: Systemic RNAi SIDes with endosomes. Rocheleau CE. Curr Biol, 2012 Oct 23. PMID 23098595
  3. Distinct pathways for export of silencing RNA in Caenorhabditis elegans systemic RNAi. Yoshida K, et al. iScience, 2023 Oct 20. PMID 37854694, Free PMC Article
  4. An endomembrane zinc transporter negatively regulates systemic RNAi in Caenorhabditis elegans. Dejima K, et al. iScience, 2023 Jun 16. PMID 37305693, Free PMC Article
  5. Tissue-specific overexpression of systemic RNA interference components limits lifespan in C. elegans. Camara H, et al. Gene, 2024 Feb 15. PMID 37984536

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in RNA transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in RNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in late endosome IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Systemic RNA interference defective protein 5
NP_509168.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    6904721..6905849
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076767.6 → NP_509168.1  Systemic RNA interference defective protein 5 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509168.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q19443
    Conserved Domains (1) summary
    pfam17204
    Location:2 → 67
    Sid-5; Sid-5 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q19443.1

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