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nep-8 Peptidase M13 C-terminal domain-containing protein;Peptidase_M13 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 184631, updated on 2-Nov-2024

Summary

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Official Symbol
nep-8
Official Full Name
Peptidase M13 C-terminal domain-containing protein;Peptidase_M13 domain-containing protein
Primary source
WormBase:WBGene00017553
Locus tag
CELE_F18A12.4
See related
AllianceGenome:WB:WBGene00017553
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human KEL (Kell metallo-endopeptidase (Kell blood group)) and ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nep-8 in Genome Data Viewer
Location:
chromosome: II
Exon count:
13
Sequence:
Chromosome: II; NC_003280.10 (3403835..3406851)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Neprilysin Neighboring gene NEPrilysin metallopeptidase family Neighboring gene pseudo Neighboring gene FBA_2 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Increasing Complexity of the N-Glycome During Caenorhabditis Development. Wilson IBH, et al. Mol Cell Proteomics, 2023 Mar. PMID 36717059, Free PMC Article
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Peptidase M13 C-terminal domain-containing protein;Peptidase_M13 domain-containing protein
NP_001309548.1
  • Confirmed by transcript evidence
NP_001309549.1
  • Confirmed by transcript evidence
NP_001309550.1
  • Confirmed by transcript evidence
NP_001309551.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    3403835..3406851
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001322721.2 → NP_001309548.1  Peptidase_M13 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MCS3
    Conserved Domains (1) summary
    cd08662
    Location:76 → 664
    M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I

  2. NM_001322722.4 → NP_001309549.1  Peptidase_M13 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MBF3
    Conserved Domains (1) summary
    cd08662
    Location:76 → 625
    M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I

  3. NM_001322723.3 → NP_001309550.1  Peptidase_M13 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MAX6
    Conserved Domains (1) summary
    cd08662
    Location:4 → 481
    M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I

  4. NM_001322724.3 → NP_001309551.1  Peptidase M13 C-terminal domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MAS8
    Conserved Domains (1) summary
    cl14813
    Location:137 → 442
    GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
Nucleotide Protein
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