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nlp-7 Neuropeptide-like protein 7 [ Caenorhabditis elegans ]

Gene ID: 184647, updated on 2-Nov-2024

Summary

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Official Symbol
nlp-7
Official Full Name
Neuropeptide-like protein 7
Primary source
WormBase:WBGene00003745
Locus tag
CELE_F18E9.2
See related
AllianceGenome:WB:WBGene00003745
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in several processes, including determination of adult lifespan; positive regulation of egg-laying behavior; and response to caloric restriction. Is expressed in egg-laying apparatus and nervous system. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nlp-7 in Genome Data Viewer
Location:
chromosome: X
Exon count:
4
Sequence:
Chromosome: X; NC_003284.9 (8593181..8594036)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Clip domain-containing protein Neighboring gene DUF148 domain-containing protein;Secreted protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Local neuropeptide signaling modulates serotonergic transmission to shape the temporal organization of C. elegans egg-laying behavior. Banerjee N, et al. PLoS Genet, 2017 Apr. PMID 28384151, Free PMC Article
  2. EGL-38/Pax coordinates development in the Caenhorhabditis elegans egg-laying system through EGF pathway dependent and independent functions. Webb Chasser AM, et al. Mech Dev, 2019 Oct. PMID 31398431, Free PMC Article
  3. Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN-1. Park SK, et al. Aging Cell, 2009 Jun. PMID 19627265, Free PMC Article
  4. Presynaptic Gαo (GOA-1) signals to depress command neuron excitability and allow stretch-dependent modulation of egg laying in Caenorhabditis elegans. Ravi B, et al. Genetics, 2021 Aug 9. PMID 34037773, Free PMC Article
  5. Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans. Park SK, et al. FASEB J, 2010 Feb. PMID 19783783, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Presynaptic Galphao (GOA-1) signals to depress command neuron excitability and allow stretch-dependent modulation of egg laying in Caenorhabditis elegans.
    Title: Presynaptic Gαo (GOA-1) signals to depress command neuron excitability and allow stretch-dependent modulation of egg laying in Caenorhabditis elegans.
  2. We demonstrate that the modulatory effects of the uv1 cells are mediated by peptides encoded by the nlp-7 and flp-11 genes that act locally to inhibit circuit activity, primarily by inhibiting vesicular release of serotonin from HSN motor neurons.
    Title: Local neuropeptide signaling modulates serotonergic transmission to shape the temporal organization of C. elegans egg-laying behavior.
  3. We conclude that two novel pathways, NLP-7 signaling and endocytosis by coelomocytes, are required for life extension under dietary restriction in C. elegans.
    Title: Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to caloric restriction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to caloric restriction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to paraquat IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to paraquat IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Neuropeptide-like protein 7
NP_001257062.1
  • Confirmed by transcript evidence
NP_001257063.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    8593181..8594036
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001270134.3 → NP_001257063.1  Neuropeptide-like protein 7 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257063.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H8W3Y5, Q19569

  2. NM_001270133.4 → NP_001257062.1  Neuropeptide-like protein 7 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257062.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q19569
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q19569.1

Gene LinkOut

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