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ncs-4 EF-hand domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 184757, updated on 2-Nov-2024

Summary

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Official Symbol
ncs-4
Official Full Name
EF-hand domain-containing protein
Primary source
WormBase:WBGene00008998
Locus tag
CELE_F21A10.1
See related
AllianceGenome:WB:WBGene00008998
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in regulation of signal transduction. Is expressed in body wall musculature; diagonal muscle; head neurons; tail neurons; and vulval muscle. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ncs-4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
8
Sequence:
Chromosome: X; NC_003284.9 (10176521..10180662)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene SCP domain-containing protein Neighboring gene SCP domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Myelin regulatory factor homolog 2, N-terminal Neighboring gene Arrestin C-terminal-like domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. KChIP-like auxiliary subunits of Kv4 channels regulate excitability of muscle cells and control male turning behavior during mating in Caenorhabditis elegans. Chen X, et al. J Neurosci, 2015 Feb 4. PMID 25653349, Free PMC Article
  2. The relationship between intraflagellar transport and upstream protein trafficking pathways and macrocyclic lactone resistance in Caenorhabditis elegans. Brinzer RA, et al. G3 (Bethesda), 2024 Mar 6. PMID 38227795, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
EF-hand domain-containing protein
NP_001367169.1
  • Confirmed by transcript evidence
NP_001368159.1
  • Confirmed by transcript evidence
NP_509708.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    10176521..10180662
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077307.6 → NP_509708.2  EF-hand domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509708.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EGM2
    Conserved Domains (2) summary
    COG5126
    Location:41 → 211
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:101 → 149
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. NM_001381078.1 → NP_001367169.1  EF-hand domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A6PVB9
    Conserved Domains (1) summary
    COG5126
    Location:9 → 132
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  3. NM_001381077.1 → NP_001368159.1  EF-hand domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    K8ES99
    Conserved Domains (1) summary
    COG5126
    Location:41 → 200
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
Nucleotide Protein
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