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F23C8.7 Tyrosine-protein kinase [ Caenorhabditis elegans ]

Gene ID: 184892, updated on 2-Nov-2024

Summary

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Official Symbol
F23C8.7
Official Full Name
Tyrosine-protein kinase
Primary source
WormBase:WBGene00017736
Locus tag
CELE_F23C8.7
See related
AllianceGenome:WB:WBGene00017736
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein tyrosine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human FER (FER tyrosine kinase) and FES (FES proto-oncogene, tyrosine kinase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See F23C8.7 in Genome Data Viewer
Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (2422153..2425185, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene PDZ domain-containing protein Neighboring gene Electron transfer flavoprotein subunit beta Neighboring gene Charged multivesicular body protein 1b Neighboring gene non-specific serine/threonine protein kinase Neighboring gene Protein TIPIN homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Tyrosine-protein kinase
NP_490975.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    2422153..2425185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058574.4 → NP_490975.1  Tyrosine-protein kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490975.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9TXI2
    Conserved Domains (3) summary
    smart00219
    Location:120 → 374
    TyrKc; Tyrosine kinase, catalytic domain
    cd10361
    Location:4 → 98
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cd00192
    Location:124 → 375
    PTKc; Catalytic domain of Protein Tyrosine Kinases
Nucleotide Protein
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