Pax2 paired box 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pax2provided by MGI
Official Full Name: paired box 2provided by MGI
Primary source: MGI:MGI:97486
See related: Ensembl:ENSMUSG00000004231 AllianceGenome:MGI:97486
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Opdc; Pax-2
Summary: Enables C2H2 zinc finger domain binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including kidney development; negative regulation of apoptotic process involved in development; and nervous system development. Acts upstream of or within several processes, including kidney development; mesenchymal to epithelial transition; and ureter morphogenesis. Located in nucleus. Part of protein-DNA complex. Is expressed in several structures, including central nervous system; embryo ectoderm; embryo mesenchyme; genitourinary system; and sensory organ. Used to study renal coloboma syndrome. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 7; renal Wilms' tumor; and renal coloboma syndrome. Orthologous to human PAX2 (paired box 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in kidney adult (RPKM 7.7), genital fat pad adult (RPKM 5.8) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 38.09 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (44735040..44826708)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (44746601..44838269)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Impaired neural circuitry of hippocampus in Pax2 nervous system-specific knockout mice leads to restricted repetitive behaviors.
Title: Impaired neural circuitry of hippocampus in Pax2 nervous system-specific knockout mice leads to restricted repetitive behaviors.
Mice with a Pax2 missense variant display impaired glomerular repair.
Title: Mice with a Pax2 missense variant display impaired glomerular repair.
PAX2 is regulated by estrogen/progesterone through promoter methylation in endometrioid adenocarcinoma and has an important role in carcinogenesis via the AKT/mTOR signaling pathway.
Title: PAX2 is regulated by estrogen/progesterone through promoter methylation in endometrioid adenocarcinoma and has an important role in carcinogenesis via the AKT/mTOR signaling pathway.
Pax protein depletion in proximal tubules triggers conserved mechanisms of resistance to acute ischemic kidney injury preventing transition to chronic kidney disease.
Title: Pax protein depletion in proximal tubules triggers conserved mechanisms of resistance to acute ischemic kidney injury preventing transition to chronic kidney disease.
Decreased Microglia in Pax2 Mutant Mice Leads to Impaired Learning and Memory.
Title: Decreased Microglia in Pax2 Mutant Mice Leads to Impaired Learning and Memory.
Cyclin-dependent kinase 4-related tubular epithelial cell proliferation is regulated by Paired box gene 2 in kidney ischemia-reperfusion injury.
Title: Cyclin-dependent kinase 4-related tubular epithelial cell proliferation is regulated by Paired box gene 2 in kidney ischemia-reperfusion injury.
Increased repetitive self-grooming occurs in Pax2 mutant mice generated using CRISPR/Cas9.
Title: Increased repetitive self-grooming occurs in Pax2 mutant mice generated using CRISPR/Cas9.
Multiple roles for Pax2 in the embryonic mouse eye.
Title: Multiple roles for Pax2 in the embryonic mouse eye.
Reduced PAX2 expression in murine fallopian tube cells enhances estrogen receptor signaling.
Title: Reduced PAX2 expression in murine fallopian tube cells enhances estrogen receptor signaling.
Pax2 is essential for proliferation and osteogenic differentiation of mouse mesenchymal stem cells via Runx2.
Title: Pax2 is essential for proliferation and osteogenic differentiation of mouse mesenchymal stem cells via Runx2.

Submit: New GeneRIF Correction See all GeneRIFs (68)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (3)
Spontaneous (1) 1 citation
Targeted (9) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Pax2 (e-PCR), detects polymorphism
- UniSTS:546921

RH80285 (e-PCR)
- UniSTS:88437

D11Bir2 (e-PCR), detects polymorphism
- UniSTS:141710

Pax2 (e-PCR), detects polymorphism
- UniSTS:470672

PMC19453P1 (e-PCR)
- UniSTS:271774

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables C2H2 zinc finger domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription factor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in brain morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in central nervous system development	IEP Inferred from Expression Pattern more info	PubMed
involved_in cochlea development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cochlea morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cochlea morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cochlea morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dopaminergic neuron differentiation	TAS Traceable Author Statement more info	PubMed
involved_in glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in inner ear morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within inner ear morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inner ear morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within kidney development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesenchymal to epithelial transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesenchymal to epithelial transition involved in metanephros morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in mesodermal cell fate specification	IDA Inferred from Direct Assay more info	PubMed
involved_in mesonephric duct development	IEP Inferred from Expression Pattern more info	PubMed
involved_in mesonephric duct development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesonephric tubule development	IEP Inferred from Expression Pattern more info	PubMed
involved_in mesonephric tubule development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesonephric tubule formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesonephros development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesonephros development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metanephric collecting duct development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metanephric distal convoluted tubule development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metanephric epithelium development	IEP Inferred from Expression Pattern more info	PubMed
involved_in metanephric mesenchymal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metanephric mesenchyme development	IDA Inferred from Direct Assay more info	PubMed
involved_in metanephric nephron tubule formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within metanephros development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within metanephros development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process involved in metanephric collecting duct development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process involved in metanephric nephron tubule development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mesenchymal cell apoptotic process involved in metanephros development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of reactive oxygen species metabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nephric duct formation	IDA Inferred from Direct Assay more info	PubMed
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in optic chiasma development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in optic cup morphogenesis involved in camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in optic nerve development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in optic nerve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in optic nerve structural organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pancreas development	IEP Inferred from Expression Pattern more info	PubMed
involved_in paramesonephric duct development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of branching involved in ureteric bud morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of metanephric DCT cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of metanephric glomerulus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of optic nerve formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in pronephric field specification	IEP Inferred from Expression Pattern more info	PubMed
involved_in pronephros development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of metanephric nephron tubule epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of metanephros size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of metanephros size	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of programmed cell death	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinal pigment epithelium development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in stem cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in ureter development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ureter maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ureter morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within ureter morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within ureteric bud development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in urogenital system development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within urogenital system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vestibulocochlear nerve formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in centriolar satellite	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule organizing center	ISO Inferred from Sequence Orthology more info
located_in microtubule organizing center	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-DNA complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: paired box protein Pax-2

Names: optic disc coloboma; paired box gene 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001368743.1 → NP_001355672.1 paired box protein Pax-2 isoform 1

Status: VALIDATED

Source sequence(s)

AC131105, AC138457

UniProtKB/Swiss-Prot

A7E2R6, P32114

Conserved Domains (3) summary

smart00351
Location:16 → 140

PAX; Paired Box domain

pfam12403
Location:305 → 390

Pax2_C; Paired-box protein 2 C terminal

cl00084
Location:255 → 278

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
NM_001368744.1 → NP_001355673.1 paired box protein Pax-2 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC131105, AC138457

UniProtKB/Swiss-Prot

A7E2R6, P32114

UniProtKB/TrEMBL

A0AAQ4VMW4

Related

ENSMUSP00000160022.1, ENSMUST00000249925.1

Conserved Domains (3) summary

smart00351
Location:47 → 171

PAX; Paired Box domain

pfam12403
Location:313 → 423

Pax2_C; Paired-box protein 2 C terminal

cl00084
Location:263 → 286

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
NM_001368745.1 → NP_001355674.1 paired box protein Pax-2 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC131105, AC138457

UniProtKB/Swiss-Prot

A7E2R6, P32114

Conserved Domains (3) summary

smart00351
Location:46 → 170

PAX; Paired Box domain

pfam12403
Location:312 → 422

Pax2_C; Paired-box protein 2 C terminal

cl00084
Location:262 → 285

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
NM_001368746.1 → NP_001355675.1 paired box protein Pax-2 isoform 4

Status: VALIDATED

Source sequence(s)

AC131105, AC138457

Consensus CDS

CCDS89397.1

UniProtKB/Swiss-Prot

A7E2R6, P32114

UniProtKB/TrEMBL

G3X8Q7

Related

ENSMUSP00000004340.5, ENSMUST00000004340.12

Conserved Domains (3) summary

smart00351
Location:15 → 139

PAX; Paired Box domain

pfam12403
Location:304 → 414

Pax2_C; Paired-box protein 2 C terminal

cl00084
Location:254 → 277

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
NM_001368747.1 → NP_001355676.1 paired box protein Pax-2 isoform 5

Status: VALIDATED

Source sequence(s)

AC131105, AC138457

UniProtKB/Swiss-Prot

A7E2R6, P32114

Conserved Domains (3) summary

smart00351
Location:16 → 140

PAX; Paired Box domain

pfam12403
Location:282 → 367

Pax2_C; Paired-box protein 2 C terminal

cl00084
Location:232 → 255

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
NM_001368748.1 → NP_001355677.1 paired box protein Pax-2 isoform 6

Status: VALIDATED

Source sequence(s)

AC131105, AC138457

UniProtKB/Swiss-Prot

A7E2R6, P32114

Conserved Domains (3) summary

smart00351
Location:15 → 139

PAX; Paired Box domain

pfam12403
Location:281 → 366

Pax2_C; Paired-box protein 2 C terminal

cl00084
Location:231 → 254

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
NM_001368749.1 → NP_001355678.1 paired box protein Pax-2 isoform 8

Status: VALIDATED

Source sequence(s)

AC131105, AC138457

UniProtKB/Swiss-Prot

A7E2R6, P32114

Conserved Domains (3) summary

smart00351
Location:15 → 139

PAX; Paired Box domain

pfam12403
Location:281 → 391

Pax2_C; Paired-box protein 2 C terminal

cl00084
Location:231 → 254

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
NM_001368750.1 → NP_001355679.1 paired box protein Pax-2 isoform 9

Status: VALIDATED

Source sequence(s)

AC131105, AC138457

UniProtKB/Swiss-Prot

A7E2R6, P32114

Conserved Domains (3) summary

smart00351
Location:15 → 139

PAX; Paired Box domain

pfam12403
Location:281 → 338

Pax2_C; Paired-box protein 2 C terminal

cl00084
Location:231 → 254

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
NM_001368751.1 → NP_001355680.1 paired box protein Pax-2 isoform 10

Status: VALIDATED

Source sequence(s)

AC131105, AC138457

UniProtKB/Swiss-Prot

A7E2R6, P32114

Conserved Domains (3) summary

smart00351
Location:16 → 140

PAX; Paired Box domain

pfam12403
Location:282 → 344

Pax2_C; Paired-box protein 2 C terminal

cl00084
Location:232 → 255

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
NM_011037.5 → NP_035167.4 paired box protein Pax-2 isoform 7

See identical proteins and their annotated locations for NP_035167.4

Status: VALIDATED

Source sequence(s)

AC131105, AC138457

Consensus CDS

CCDS37998.2

UniProtKB/Swiss-Prot

A7E2R6, P32114

UniProtKB/TrEMBL

A0A0R4J267

Related

ENSMUSP00000134661.2, ENSMUST00000174490.9

Conserved Domains (3) summary

smart00351
Location:16 → 140

PAX; Paired Box domain

pfam12403
Location:282 → 392

Pax2_C; Paired-box protein 2 C terminal

cl00084
Location:232 → 255

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.